What are the types of lungs diseases and their cures with stem cells?
Pulmonary fibrosis is the solidifying and scarring of the lung tissue. The term idiopathic signifies the cause is unidentified and befallen unexpectedly. Diffuse parenchymal lung disease (DPLD) & Interstitial lung disease (ILD) are an assemblage of lung diseases that affect the tissue and spaces around the air sacs (interstitium) in the lungs (alveoli). This family of numerous lung ailments befalls an injury to the lungs that fails to reconcile appropriately for several reasons. Zones of the lungs that are susceptible to injuries consist of:
- Pulmonary capillary endothelium
- Basement membrane – a specialized form of extracellular matrix (ECM)
- Alveolar epithelium – functional and physical barrier of hazardous environmental agents
- Perilymphatic lung tissue
- Perivascular tissue
Alveolar fibrosis – fibroid lung disease
Under common situations, the human body can initiate self-repair of the lungs using paracrine cell gesturing but for some patients with interstitial lung disease, this standard lung repair procedure breakdowns occasioning in the tissue around alveoli air pouches to solidify and become mutilated. Thickened mutilated lung tissue makes it challenging for oxygen to pass back into the bloodstream occasioning in impairment to both the whole cardiovascular system and lungs. The term interstitial lung disease is used by pulmonologists to differentiate these kinds of lung diseases from others such as COPD and obstructive airways diseases. If left untreated, interstitial lung disease leads to fibrotic scarring of the lungs identified as pulmonary fibrosis. Idiopathic pulmonary fibrosis generally gets detected after radiographic lung scans begin to show pleural-based fibrosis with honeycombing in the lungs and multiplying fibroblasts (fibroblastic foci.) IPF and fibroid lung disease generally begins with a manifestation of swelling in the alveoli. The alveoli are the small air sacs in the lungs where the exchange of carbon dioxide and oxygen ensues. The brittle lining of the alveoli permits this gas exchange. Once these alveoli become swollen and impaired in some way, the body’s response would be to trigger the immune response and to reconcile the impaired alveoli. This causes scarring and solidifying of the alveolar walls. Unluckily, the solidified and scarred alveoli cannot perform resourcefully during gas exchange. This eventually results in a lesser quantity of oxygen that can be conveyed into the body and less carbon dioxide that can be ejected out.
Signs & symptoms of pulmonary fibrosis
Some of the common signs and symptoms that are there in patients spotted with onset idiopathic pulmonary fibrosis are:
- Severe shortness of breath. This is instigated by heart ailment or the reduced quantity of oxygen that the body gets because of the ineffective, affected alveoli. It gets worse with physical activity as the body is aiming to get more oxygen.
- Continuous dry cough
- Clubbing sensations of the finger and toenails. Clubbing is the inflammation in the base of the finger and generally accompanied by cyanosis (bluish discoloration of the nails.) This is a sign of hypoxia or reduced level of oxygen in the tissue. This sign often establishes later on the ailment progress and end-stage pulmonary fibrosis.
- Decrease of lung capacity or airflow obstructions occasioning in untimely exhaustion.
Traditional vs. modern treatments for ILD & lung fibrosis
Formerly, there were traditionally nominal options for handling chronic progressive lung ailments such as COPD and idiopathic pulmonary fibrosis. Even now, there are numerous clinical trials for trying to cure interstitial lung diseases, familial pulmonary fibrosis and idiopathic lung sclerosis using revised gene therapies but as of now, there are no operative pharmaceutical medicine based treatments sanctioned for treatments. In some circumstances, steroids are recommended to help reduce the inflammation or mucomyst (Acetylcysteine) to decrease symptoms, but the effects are provisional and do nothing to the underlying reason of the disease. Lung transplants are another alternative for some but are considered very invasive, high-risk and are generally only offered to advanced end-stage pulmonary fibrosis patients. Although it has its confines, modified MSC stem cell treatment for interstitial lung disease offers a natural alternate to lung transplants for pulmonary fibrosis and anti-fibrotic medicines. Your stem cells are fundamentally the body’s drugstore. Stem cells are the building blocks of your whole body. These kinds of potent cells are named “totipotent” cells as they can change/segregate into any cell, tissue or bone in the human body. When used appropriately, MSC+ stem cells can aid with the loss of lung capability/reduced lung function by concentrating on the damaged or limited linings of the alveoli that are at the root of the ailment. The objective of the boosted MSC+ stem cell treatment for pulmonary fibrosis and lung hardening ailment is to help the body in detouring fibrotic scarring by restoring new healthy tissues and blood vessels via a process named as angiogenesis.