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Down Syndrome

Down Syndrome

Down syndrome is a chromosomal ailment that causes damage in physical and cognitive growth of a kid. It is the most common reason of mental retardation. People with Down syndrome have typical features such as a flat face and a short neck. These features differ from person to person. It is a lifetime condition. But with suitable care and support, kids with Down syndrome can grow up to have healthy and prolific life. Down syndrome is instigated by an occurrence of extra chromosome 21. Chromosomes carry the genes that tutor the body to develop in certain ways and to implement certain functions. Maximum cells of the human body encompass 23 pairs of chromosomes, one set of chromosome from each parent. Individuals with Down syndrome have 47 chromosomes. In rare circumstances, other chromosome complications can also cause Down syndrome. Having additional or abnormal chromosome interrupts the normal course of development and leads to the physical features and intellectual and developmental in capacities related with the syndrome.

The most common symptoms witnessed in kids with Down syndrome are:

  • Distinctive facial features such as a flat face, slanting eyes, small ears,short neck, arm and legs and small mouth
  • Single, deep rumples across the center of the palm
  • A single flexion furrow of the fifth finger
  • Lower muscle tone and wobbly joints
  • Below-average astuteness

Furthermore, kids with Down syndrome are also born with heart, intestine, ear, or breathing complications. These disorders often result in other complications such as airway infections or hearing loss.

The conventional treatment approaches aid in the management of associated symptoms and improving the physical and intellectual aptitudes, reestablishing the patient to daily life. Stem cell therapy,quite the reverse, targets to stimulate the repair mechanisms and treat the core impairment in the nervous tissue accompanied by management of impairments seen in affected folks. Cellular therapy using autologous bone marrow derived mono nuclear cells has been proposed as a treatment approach in numerous neurological ailments. These cells have the propensity to migrate and offer repair mechanisms such as endogenous neurogenesis, angiogenesis and synaptogenesis of the impaired neurons. Along with that, these decrease inflammation and systemic immunological processes thus augmenting the recovery process.

How can the diagnosis be done after birth?

A diagnosis can be done on the basis of the facial features and deferred development typical of Down’s syndrome. Along with that, a chromosomal analysis known as karo type test can ratify the diagnosis of Down’s Syndrome post birth.

When is the correct time to seek intervention for a child diagnosed with Down’s syndrome?

The intervention can begin instantaneously after the diagnosis of the kid. Timely intervention helps the youngster to attain his optimum level of development rapider.

Will the other kid also have Down’s Syndrome?

It is imperative for the parents to undergo genetic counseling so as to determine the risk when they plan for the second child. However, there are no identified behavioral or environmental reasons of Down’s Syndrome.

Are children with Down’s syndrome only born to older parents?

80% of kids with Down’s Syndrome are born to females younger than 35. However, the likelihood of the kid having the syndrome does upsurge with maternal age.

Can the child get married and have kids in the future? What are the probabilities of the baby having Down’s syndrome?

A kid with Down’s syndrome can get married and have children as around 50% of all women with Down’s Syndrome are fertile and have regular menstrual cycles. However, between 35 to 50 percent of kids born to mothers with Down’s Syndrome have a probability of being born with Trisomy 21 or other developmental in capacities.

Will the kid’s facial structure change after Stem Cell Therapy?

Stem Cell Therapy works on improving the brain functioning in the kid so therefore, the facial features remain the same.

How many times is Stem Cell Therapy required for our child?

The number depends on a multiplicity of factors like the impairment in the brain and the severity of the condition. Whether another round of stem cell therapy is necessary or not is determined on the basis of clinical follow up and comparison of the PET-CT Scan 6 months after the first stem cell therapy. Depending on the outcome of all these investigations at the time of follow up, the need for another shot is indicated.

Can there be any side-effects of this treatment on the kid?

No side effects have been noted until now as no foreign entity is inserted into the kid’s body.

Is there a chance of his condition worsening after doing this treatment?

This treatment does not cause any worsening in the condition of the kid as it works on boosting the development of the child.

Can stem cell therapy result in speech development in the child?

Improvements in speech are noted in maximum of the cases. The range can be extensive with some children going from monosyllabic speech to developing the aptitude to speak small sentences.

Can the child be cured of Down’s syndrome after stem cell therapy?

Stem cell therapy addresses the mutilation in the brain and boosts the mental development. It does not concentrate on the physical problems associated with the condition like hypothyroidism, heart problems, facial configuration etc.

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