Optic nerve hypoplasia (ONH) befalls from the underdevelopment of the optic nerve, which carries neuronal transmission from the retina in the eye to the brain1. Septo-optic dysplasia (SOD) – also recognized as de Morsier syndrome – is a subtype of ONH and ascends from underdevelopment of the optic nerve, pituitary gland dysfunction and deficiency of the septum pellucidum, which is a midline region of the brain. SOD ascends from shortcomings during the embryological development of babies and studies show that ONH might be connected to gene defects as well as embryo exposure to infections. Along with tis he deficiency of vision which is a characteristic symptom of ONH, SOD also elicits other symptoms such as pituitary deficiency, autistic behaviors, epileptic seizures, etc.
Few conventional treatment choices are available for patients detected with ONH-SOD, which typically concentrate on assisting the patients to cope with their incapacity. However, nobody of them are essentially treating the loss of optic nerve function. Stem cells have the aptitude to rejuvenate nerve cells in the optic nerve, permitting ONH-SOD patients to gain some vision.
Stem cell processing method
Umbilical cord collection and preliminary testings
It is a common practice in India for mommies to voluntarily donate the umbilical cord blood from the birth of their fit full-term kids. Every mom who enters a hospital in India to give birth is spontaneously tested for all main sicknesses. Comprehensive family histories are also taken from each mother before donation. Only females who have been fully screened and found to be totally healthy are allowable to donate their umbilical cord and umbilical cord blood.
Second round of testing
The second step in the screening procedure happens in laboratory once the collected samples have been verified negatively for communicable ailments; it is then transported to our laboratories and officially becomes the property. From this phase, it is mandatory for each and every sample to be processed and provided to patients. The gathered sample starts a second round of testing and while following donor’s prerequisite also carries out testing for cytomegalovirus, micro-organisms (aerobic bacteria, anaerobic bacteria, fungi, etc.), survival rate, stem cell surface indicators and stem cell biological characteristics (colony forming aptitude, differential capability) in each step to safeguard the highest quality to its cell products.
The stem cells derived from each umbilical cord are sowed into a flask filled with culture medium. This medium does not have any animal products (such as fetal calf serum) but it is heightened with cell growth factors. The flasks are positioned in a sterilized, temperature and humidity controlled incubator. The stem cells are lengthened in the culture medium. Once the culturing is done, the culture mediums are splashed away and are harvested.
The cell products are then cryo-preserved and stored at a consistent -196 degree Celsius temperature with automatic supplement of liquid nitrogen using the exceedingly advanced Thermogenesis BioArchive system. This technology permits for integrated control rate of freezing that absolutely avoids unexpected drops in temperature. Our cryo-preservation storage equipment is also fortified with 24h real-time control system and in any situation of power-failure or other emergency; a redundant fail-safe power supply guarantees that normal operation is implemented. Our vacuum protection system can uphold appropriate temperature for 20 days without supplement of liquid nitrogen.
Packing and transport
All consignments of stem cells undergo final testing. During this procedure, they are also tested for quantity and quality. Once the stem cells are reckoned safe, each unit is positioned into either a sterile vial or a sterile IV bag for future transplantation. All merchandises are separately cataloged and traced while in transit. Our cell transplants come to pass two to three days a week. All of our cells are processed on an as-needed basis. All of our cell products are treated and kept fresh, giving us the highest stem cell sustainability count and the maximum effectiveness.
The purpose of our stem cell treatment is to reinstate neurological function in the brain/spinal cord lesion region, thus, various kinds of improvement are conceivable after our treatment and our previous patients have experienced the following:
- Improved visual insight
- Improved light perception
- Enlarged visual field
- Perkier night vision
- Abridged nystagmus
- Enriched strabismus
- Better-quality hormonal deficiencies
- Reduced autistic symptoms
It is vital to remember that as for any medical treatment, improvements cannot be promised. Please contact us for more info regarding the possible improvements for any specific case.