Can Stem Cells Help Kidney Disease Patients? Read On!

Posted On February 12, 2019 By stemcellcareindia Stem Cell Care / No Comments

Kidneys are the body’s waste disposal system, sieving our blood and vacuuming out all the waste products. Our kidneys have a restricted capability to help overhaul themselves but if somebody suffers from chronic kidney disease then their kidneys are gradually overwhelmed and that results in end-stage renal disease. At that point, the patient’s choices are restricted to dialysis or an organ transplant.

Chronic renal failure is an imperative clinical issue with substantial socioeconomic impact universally. Notwithstanding improvements in renal replacement therapies and organ transplantation, poor quality of life for dialysis patients and lengthy transplant waiting lists remain chief concerns for nephrologists treating this disorder. There is consequently a persistent requirement for innovative therapies to stimulate renal cellular repair and tissue remodeling. Over the last decade, progresses in the arena of regenerative medicine permitted development of cell therapies appropriate for kidney repair. Mesenchymal stem cells (MSCs) are undifferentiated cells that have immunomodulatory and tissue trophic attributes and the aptitude to segregate into numerous cell types. Studies in animal models of chronic renal failure have exposed an exceptional potential of these cells for improving function and regenerating the impaired kidney. Nonetheless, numerous limitations relating to insufficient engraftment, trouble to monitor and troublesome effects of MSCs remain to be addressed. Hostile effects observed following intravascular administration of MSCs consist of immune rejection, adipogenic differentiation, malevolent transformation and prothrombotic events. Nevertheless, maximum studies specify an amazing competence of MSCs to attain kidney repair. This review recapitulates the regenerative potential of MSCs to offer functional retrieval from renal failure, concentrating on their application and the present challenges facing clinical translation.

Mesenchymal stem cells (MSCs) can be isolated from a multiplicity of tissues, segregate into several cell lineages, and have unique immunomodulatory properties that enhance inflammation and immune responses, instituting a promising tool to simplify renal repair. MSCs are well-defined by the incidence of plastic-adherent cells under standard culture conditions, capability to segregate into osteoblasts, adipocytes and chondroblasts in vitro, expression of usual surface markers (CD29, CD44, CD73, CD90, CD105, and CD166) and the deficiency of CD45, CD34, CD14 or CD11b, CD79α or CD19 and HLA-DR surface molecules [10]. In recent years, investigational studies have revealed the potential of MSCs to improve renal function in numerous models of CKD, and numerous clinical studies have specified their security and effectiveness in CKD. Nonetheless, numerous hurdles need to be addressed before clinical translation. This review recapitulates the existing state of MSC transplantation for CKD, concentrating on their mechanisms of renal repair, hitches and obstacles for clinical translation, and prospective methodologies to overcome them.

Why stem cells help with chronic kidney disease (CKD)

Can stem cells help kidney disease? Yeas! The therapeutic targets in nephrology are the decrease of injury, the postponement of progression, or renal replacement therapy comprising of either renal transplantation or dialysis. Lately, new therapeutic strategies for tissue repair have arisen and one of the most encouraging methodologies is the usage of stem cells to decrease injury in Chronic Kidney Disease (CKD). Mesenchymal Stem Cells (MSC), centered on their capability to segregate into several kinds of functional cells, and anti-inflammatory properties, has materialized as the principal contenders in treating Chronic Kidney Disease (CKD).

Chronic kidney disease complications

The major Chronic Kidney Disease complications consist of: severe fluid retention including in the lungs (pulmonary edema), cardiovascular ailments, weak bones and amplified frequency of fractures, impotence, central nervous system impediments and abrupt vicissitudes in blood electrolyte levels, particularly potassium, which would be life-threatening in some circumstances.

Stem cells are the humans bodies overhaul mechanism. Stem cells can segregate into any functional tissue cells. Kidney cells necrosis and/or decreased kidney functions can be seen in uncharacteristic creatinine levels. The approved stem cell transplants for renal failure aid to restock the required kidney cells and thus encourage a more normal healthy kidney function. There are two categories of stem cells treatments that might be used in the regenerative protocols for renal failure using stem cells. One part of treatment is concentrated on promoting appropriate kidney function and the other would be to restock red blood cell amounts to help reverse the decline in HGB level. The autologous mesenchymal cells are transfused back into your body via a simple blood transfusion that permits the flowing stem cells could to reach the kidneys through normal blood circulation. This revolutionary treatment for renal failure can be done with and without dialysis and demands no surgical procedure that necessitates lengthy hospital stays only at the regeneration Center. The mesenchymal stem cell treatment for kidney ailment is done in several stages but every daily sitting takes about two hours every time.

Can Optic Nerve Hypoplasia Be Cured By Stem Cell Treatment?

Posted On February 6, 2019 By stemcellcareindia Stem Cell Care / No Comments

What is the optic nerve?

The optic nerve is an assortment of more than a million nerve fibers that convey visual signals from the eye to the brain. The optic nerve develops the first trimester of intrauterine life.

What is optic nerve hypoplasia?

Optic nerve hypoplasia (ONH) is a congenital condition in which the optic nerve is underdeveloped (small).

How is optic nerve hypoplasia detected?

The scrutiny of ONH is usually made by the appearance of trivial/pale optic nerve on ophthalmoscopic checkup of the eye. It is problematic to foresee visual acuity potential on the base of optic nerve appearance. Maximum cases of ONH have no evidently recognizable cause. There are no identified racial or socioeconomic aspects in the development of ONH, nor is there an identified association with exposure to pesticides.

What visual issues are linked with optic nerve hypoplasia?

Vision impairment from ONH ranges from mild to severe and might affect one or both eyes. Nystagmus (shaking of the eyes) might be seen with both unilateral and bilateral circumstances. The occurrence of strabismus is increased with ONH.

Is optic nerve hypoplasia linked with non-visual issues?

Optic nerve hypoplasia can be related with central nervous system (CNS) deformities which put the patient in danger for other issues, including seizure ailment and developmental postponement. Hormone insufficiencies befall in maximum youngsters, irrespective of associated midline brain aberrations or pituitary gland aberrations on MRI. In fact, maximum kids with growth hormone insufficiency have a normal MRI.

What tests should be done for kids with optic nerve hypoplasia?

An MRI scan is specified for all kids with optic nerve hypoplasia. Assessment by an endocrinologist should be obligatory for all patients under five years of age.

Does optic nerve hypoplasia get worse over time?

At large, ONH is a steady and non-progressive condition which does not worsen. Vision might improve marginally and nystagmus might decline over time.

Diagnosis of ONH explained in detail

Diagnosis of ONH is chiefly clinical. Currently, laboratory or radiographic inspections to establish the diagnosis of ONH are non-existent. ONH diagnosis is via ophthalmic substantiation of a trivial optic disc that is pale or grayish. The disc dimensions are measured by taking the distance from the optic nerve to the macula. ONH might also be accompanied by meandering retinal vessels that might affect both venules and arterioles. Otherwise, the vessels may be remarkably straight with abridged branching. However, in mild circumstances of ONH, the double ring sign may not be seen and the optical disc appears normal. Consequently, MRI of the intracranial visual pathways is an improved clinical diagnostic tool.

Reasons and risk factors

There is no identified reason of ONH. However, in several cases, numerous risk factors have been linked with ONH. These consist of maternal diabetes, maternal alcohol abuse and usage of anti-epileptic drugs. Others risk aspects include fetal or maternal infections such as Hepatitis B, young maternal age and preterm birth. Doctors are typically observant for any signs of hypothalamic dysfunction accompanied by any vision difficulties. For example, all kids with neonatal jaundice and recurrent hypoglycemia ought to have ophthalmoscopy examination, predominantly, if the kid experiences related temperature uncertainty. Furthermore, if a kid exhibits hormonal insufficiencies or inherited incongruity, MRI scan should be taken so as to identify intracranial abnormalities and rule out curable disorders. Growth of kids with ONH should also be scrutinized and their sexual development observed so as to forestall deferred sexual growth. They should also often undergo physical, occupational and speech therapy.

Is there any treatment for optic nerve hypoplasia?

There is nil medical or surgical treatment for ONH. However, obstruction of the better seeing eye might improve vision in the other eye. Kids with substantial vision loss in both eyes might profit from initial supportive attention by low vision experts. Stem cell treatment has not been revealed to be effective for ONH. Optic Nerve Hypoplasia (also recognized as ONH) is a condition that affects the optic nerves, which are accountable for conveying visual information between the eyes and brain. The occurrence of ONH as a chief reason of vision impairment has speedily been snowballing over the years. Individuals with ONH often experience visual sharpness, sensitivity to bright light, and outlying field loss. Consequently, they have woe recognizing faces and facial expressions. Moreover, they have challenges retrieving near and comprehensive information.

Could cell therapy treat optic nerve hypoplasia?

Can optic nerve hypoplasia be cured by stem cell treatment? Yes! There is hope for individuals living with optic nerve hypoplasia. Doctors have revealed that retrieving innovative cellular-based treatment can decelerate vision loss. Probabilities are that cell therapy could also offer new healing potentials as equated to traditional approaches of treatment. Widespread research on how live cell therapy can treat severe eye conditions is still continuing. For over a decade now, the cellular therapies have played a gigantic role in the treatment of ONH as the cells improve vision centered on their unique characteristics and variances.

Can Macular Degeneration be Cured with Stem Cells

Posted On January 26, 2019 By stemcellcareindia Muscular Dystrophy / No Comments

Macular degeneration is an ocular condition in which the central portion of the retina called the Macula breaks down occasioning in diminished vision. Generally, a genetic disposition is needed for the condition to befall and the severity will depend on both heredities and environmental aspects. Studies have long determined that aspects such as drug usage and smoking will precipitate the ailment to befall at earlier ages and will considerably make the vision worse. Smoking will upsurge the probability of the condition happening 300% and will also make it much worse than in a person that never smoked. There are also other less common kinds of macular degeneration, such as Sorsby’s disease, Best’s disease and Stargardt’s disease, which are genetic and can affect younger individuals. These are identified jointly as juvenile macular degenerative diseases. Extreme near-sightedness and other illnesses of the retina can also lead to the degeneration of the macula and while not to be muddled with age-related macular degeneration, can have the same end product of loss of central vision.

Dry Macular Degeneration

The “dry” or “atrophic” type of “macular degeneration” is typically recognized by yellowish deposits of debris in the retina. The material encompassing these deposits is generally carried away by the same blood vessels that carry nutrients to the retina. The success of this act appears to be lessened in circumstances of macular degeneration. There are numerous projected reasons for this including:

Insufficient blood circulation in the retina
Swelling
Premature aging of the sight cells because of hereditary deficiencies
Environmental aspects
Dietary aspects
Behavioral factors

One of the needs of your body for healthy life is Omega-3 fatty acids, something typically found in fish oils. A shortage of these oils can result in eye sicknesses, muscle weaknesses and skin issues, scratchy arms and legs and behavioral changes. Complementing your diet with a worthy source of Omega-3 will not only help improve your heart health and blood pressure but will be an advantage for your overall health and well being.

Macular degeneration treatments have improved in the last numerous years principally because this eye syndrome has become one of the principal reasons of blindness in individuals 50 years of age and older. With two types of the eye disease, macular degeneration that is referred to as the “wet” form of this eye ailment is treated with anti-VEGF drugs. These drugs such as Avastin and Lucentis are inoculated straight into the eye. Wet AMD is categorized by the formation of anomalous blood vessel growth as well as leakage. Treatments such as anti-VEGF drugs make the growth of these uncharacteristic blood vessels and the leakage paused. Wet AMD accounts for about 10 percent of the diagnosed circumstances, but leads to 90 percent of the sightlessness from this eye disease.

Dry macular degeneration befalls when drusen forms on the eye. This is the most common type of this eye disease, making for 90 percent of diagnosed cases and occasioning in only 10 percent of the sight lessness. There is no treatment for dry AMD but dietary supplements have been displayed to slow the evolution of this form of the eye disease. With the upsurge in the number of patients each year, research into new treatments for macular degeneration has become one of the fastest growth capacities. Research lingers and there have been sizeable advancements made in the anti-VEGF drugs as other pharmaceutical firms join the fight against this disease. Other researchers are reviewing drugs known as angiostatin corticosteroids, while others are reconnoitering more progressive forms of photo dynamic therapy. However, the most encouraging treatment for macular degeneration comes from innovation in using human stem cells. Can macular degeneration be cured with stem cells? Yes! Eye sicknesses such as ARMD damage the retina; particularly the eye disease impairs central vision. Human retinas impaired by this disease are inept to overhaul themselves. However, a report by researchers from the University of Washington recommends that the renaissance of impaired retinal cells might be possible using human stem cells. Using human embryonic stem cells and proteins to permit cell growth, researchers were able to grow cells that became progenitor cells for retinal cells. Inoculating these cells into an impaired mouse retina, these stem cells continued to develop into cones – retinal cells accountable for color. They also developed into rods – the cells that permit night vision. The stem cells also continued to develop into other retinal cells.

In summary, there are countless factors that can contribute to macular degeneration, but recent studies show that simple carbohydrates upsurge the probability of contracting and the severity of the condition. As with maximum ailments, eating the appropriate food will keep you healthier and avert some conditions. With this research, scientists hope to assess the nerve reactions and conclude if vision improved. If this proves to be efficacious, human tests using stem cells to overhaul retinas impaired by macular degeneration could befall within two or three years.

Learn About the Prime Significance of Stem Cell Therapy in India

Posted On December 22, 2018 By stemcellcareindia Stem Cell Care / No Comments

Stem cells are un-specialized or interchangeable cell of a multi cellular organism which is adept of giving upswing to indeterminately more similar variety of cells, certain other types of cell also ascends by differentiation via them and they take place of the impaired or lost cells. It plays a very fundamental role in body’s aptitude to renew and overhaul its tissues. From the above, following characteristics of stem cells can be cited: first, they are un-specialized that refurbish themselves for long periods through cell division. Second is that under some specific physiologic or investigational conditions, they can be induced to become cells with exceptional functions such as the beating cells of the heart muscle or the insulin manufacturing cells of the pancreas.

Why stem cell therapy is important?

The procedure of therapy or treatment with the assistance of stem cells is acknowledged as stem cell treatment. Research is ongoing to develop numerous sources for stem cells and to apply stem cell treatments for neurodegenerative diseases and disorders, diabetes, heart disease and other conditions. The most extensively used stem cell therapy is bone marrow transplant accompanied by therapies derived from umbilical cord blood. For over 30 years, bone-marrow has been used to treat cancer patients with disorders such as leukaemia and lymphoma; this is the solitary form of stem cell therapy that is extensively practiced. Stem cells are well-defined by their function in complex multidimensional environments called as stem cell niches. The simple site of stem cells is not enough to define a niche. The niche must have both anatomic and functional magnitudes, precisely permitting stem cells to replicate and self-renew. Adult stem cells usually have limited function without the niche. For instance, HSC, which renews the whole blood and immune system, circulate liberally, but seem to have little function outside particular anatomic locations. Chiefly, the research is going on with two types of stem cells. These are embryonic and adult. In addition to the overwhelming assurance of stem cells in numerous cellular therapies, their clinical and practical use is inhibited by numerous technical and ethical problems. The major hurdle for the clinical usage of adult stem cells is the trivial number of cells that can be isolated from any adult tissue. An outline of the prospective usage of stem cells for treatment of human disease is now traceable. The coming years will certainly inaugurate new developments and know-hows that would decode the projected therapeutic potential of stem cells to bedside medicine for patients struggling with distressing and incapacitating illnesses.

In the recent years, stem cells therapy has been evolving as the most viable option to treat variety of degenerative illnesses, which cannot be treated with the assistance of conventional treatment choices. Numerous clinical evidences have been amassed from gigantic obtain ability of data to assess the immense potential of stem cell therapy as a contemporary medicine. Various doctors are in this regard, supporting stem cell therapy in India; indicating it to be the most innovatory way to treat the root cause, with the assistance of body’s own restoring mechanism. Although, the therapeutic results are very promising, to affirm it to be the mainstream medicine; adequate clinical evidences are required, which can be gotten via huge variety of clinical trials. Thus, unquestionably, stem cells treatments are very auspicious and can prove as the prospective alternative for futuristic treatment arrangement, but are still modish for clinical applications. Stem cells are renowned to be the mother cells of our body, with the aptitude to segregate into numerous cells types, for the generation of whole cellular system. In fact, these are cells, which lay the sturdy foundation of internal metabolic paths and functioning aptitude of our body. This marvelous capability has been exploited by medical community to offer antidote to numerous diseases, ranging from spinal cord injury to mental retardation.

Technological progressions have permitted easy isolation of these stem cells from numerous sources of our body, such as bone marrow and adipose tissues. These cells are gathered from quantified sources outside the body, supplemented in the laboratory and are imbued back at the location of injury. A hefty fraction of isolated pool of stem cell is related with the existence of mesenchymal stem cells. Studies have publicized that these stem cells display sturdy anti-inflammatory properties to standardize immune system of the body. This widespread immune regulation is thought to be useful in creating an apt milieu for stem cells growth, development and differentiation. Furthermore, it has as well been predictable that mesenchymal stem cells show sturdy differentiation potential towards cells of varied lineages, like mesodermal, endodermal, ectodermal, etc. Thus, retrieval and effective therapeutic result, instantaneously after stem cells treatment can be accredited to production of appropriate micro environment for triggering resident stem cell to start a biological reaction. This, in turn can transmute a weak, non-functional tissue, into its healthier equivalent, further permitting it to be less swollen and offering considerable pain reduction as well as functional renovation.

Stem cells therapies have been frequently employed as treatment segment via last couple of decades, in treating countless aberrations related to the blood cancer; in fact, routine application of stem cells therapies have protected life of millions of kids universally, who have been struggling with lethal illnesses, such as childhood leukaemia. Furthermore, their differentiation capacity has as well been endorsed in multiplicity of clinical studies, conducted internationally to treat bone injuries, skin injuries and muscular problems. Thus far, transplantation of antilogous stem cells from multiplicity of body sources, such as bone marrow and/or adipose tissues, etc. are found to be extremely recognized. While numerous problems are still restraining their unlimited applications, like number of stem cells to be suffused, augmenting diverse routes of administration and origin of tissue specific stem cells to upsurge the therapeutic outcome. Numerous studies are ongoing in this regard, with every day bringing us one step nearer to their therapeutic application; there is still a lengthy way to efficiently apply the potential of stem cells in medicinal field.

Want to Know why Doctors Prefer to use Stem Cell Therapy These Days? Read on!

Posted On December 14, 2018 By stemcellcareindia Stem Cell Care / No Comments

Stem cells are those noteworthy cells in our body which have the propensity of developing of getting transmuted into numerous other cells and its categories, assisting to form numerous organs, or tissues or even a complete system in some people. The widespread cell division which is obvious in stem cells aids in forming cells like brain cells and RBCs.

Why do we use stem cells therapy?

Stem cell treatment has a capability to treat multitude of unanimously rambling diseases ranging from the ordinary, innocuous and non-serious to serious, deadly and life-threatening. It has become one of the most exciting areas of medicine, encompassing all expanses of current medical science.These are not classified or special; all these stem cells are totally different and adept of renewing all by themselves. These cells can keep on being sedentary for lengthy periods. These cells do not have any particular tissues or organs to address. They can transform themselves into any organ or tissue cells. These cells even substitute or overhaul all by themselves the ones in the bone marrow or gut. Liver, pancreases, heart stem cells also have the separating properties but seldom do this happen and under certain special conditions only.Stem cells are now used to treat lots of ailments and disorders, few of which are:

Diabetes
Heart Damage
Spinal Cord Injury
Ageing
Arthritis
Cirrhosis
Alzheimer’s
Cancer
Cerebral Palsy (CP)
Autism

Stem cells, which are considered as the ‘Universal’ based on the self-renewal, duplication and multi-directional differentiation features. Medicine experts work on excavating the application value for tissue repair, cell-related therapy, drug development, toxicological evaluation, disease model construction and so on. Although a sequence of studies already mined the gene and protein, however, the stem niche is principally overlooked. What we would like to discuss in this post is about the linking between the stem and immune cells. Excepting cells in stem cell niche, they will collaborate with immune ones regularly. As the chief line to defend pathogens invaders, immune cells are acknowledged as the key fundamentals to maintain vivo balance and prompt healing! However, the effect of immune on stem cells is not simplification; it will bourgeon as per the species, development phase, impaired organs or tissue, the degree of injury, stem cell characteristics and particular scrutiny. In some circumstances, the immune system might even attack normal tissues and result in the proliferation. However, scientists can apply better while treating the numerous disease if can work out the influence of immune ones.Recurrent cell renewal is an imperative branch to keep the vivo balance and research exhibits that immune ones in stem cell niche have the phenomenal effect on this progress by regulating the workout of stem cells function and maintain the balance between cell propagation and cell apotheosis. Several studies have discovered that immune cells are the part which cannot be unheeded for stem cell research, also play a significant role in tissue regeneration and damage restoration. Theoretically, aiming these immune cells will get faster the procedure of dealing with the injury in a body.

Why stem cell treatment in India?

Stem cell treatments are essential for patients where stem cells are used to avert diseases. Like stem cells from the umbilical cord treats the neurodegenerative sicknesses. These sicknesses are common in India and henceforth the treatments are also advanced. Ailments related to heart, diabetes etc. come under this category. As per research, the circumstances of brain or spinal cord injuries, blood cell formations, cardiac troubles, teeth problems, hair cell growth, vision weakening, infertility, healing of accident wounds (both internal and external), HIV etc. are thriving in the nation and more centres like the Stem cell Care India in Delhi, have appeared for better services. Here are some of the per-requisites which are anticipated from the patients before plunging into this intricate yet safe and preferred therapy:

Submission of all the authentic medical reports from anywhere around the globe
Being mentally ready for all types of counseling and queries in those sittings where the doctor explicates the side-effects and precautions for the treatment.
According to the therapy protocol, the patient should have all the medical principles followed before the patient signs the papers for consent.
Screening assessments of HIV, CMV, VDRL, HBV etc. should be done and the outcomes have to be submitted before the stem cell therapy in India.
There would be second of third stage followed by the first sitting as well, so missing any appointment won’t be in your favor or won’t do any good.

India has an amazing chance to swish ahead of other countries in stem cell therapy because:

Government of India and the Department of Biotechnology has allotted more than Rs. 300 crores in the last few years towards elementary and applied research in stem cell technology.
As contrasting to other countries, in India, a patient doesn’t have to wait for months to get an appointment.
Lots of chief business houses are investing a lot on stem cell tourism, looking after all the health and travel prerequisites of a patient with even associated service support like that of visa, interpreters, phone etc.

Success rate of stem cell therapy in India

The reckon able out comes of stem cell therapy depend on an array of aspects, for example the disease being treated, phase of the disease, age of the patient and the period between the beginning of the disease and the treatment. In several conditions such as muscular dystrophy there are exceptional clinical outcomes with more than 90% of the patients displaying an adequate clinical improvement. Otherwise, in the ailments like motor neuron abnormality, only 20% of the patients show a rational end outcome. It is also being perceived that children react very much to this therapy than older individuals On the whole, hit rate in maximum set ups across the globe as well as in India ranges between 60-80%.

What are the Diseases that Stem Cells Can Cure and How?

Posted On December 2, 2018 By stemcellcareindia Stem Cell Care / No Comments

The stem cells are principally called the “master cells” of the human body owing to their aptitude to craft all other tissues, organs, and systems in the body. The stem cells are the building blocks of your blood and immune system. They are the factory of the blood structure and recurrently make new replicas of themselves and create cells that make every other type of blood i.e. Red blood Cells, White Blood Cells and Platelets. There are essentially three sources where stem cells can be straightforwardly found.

Bone Marrow
Peripheral Blood and
Umbilical Cord Blood

Numerous researches done in this arena recommend that stem cells gotten from cord blood are comparatively more beneficial over those retrieved from bone marrow or peripheral blood since they are immunologic ally “younger” and seem to be more multipurpose. They also exhibit an imperative feature with embryonic stem cells and are able to segregate into virtually all cell varieties in the body. Secondly, it is easy to get stem cells from cord blood as they are readily gotten from the placenta at the time of delivery. Reaping stem cells from bone marrow necessitates a surgical process, implemented under general anesthesia and can cause post-operative pain or pose a minor risk to the donor. The assurance of using stem cells for medical treatments have been the attention of researches numerous projects that are displaying hopeful outcomes.

Cord blood stem cells support in the treatment of ailments such as Alzheimer’s and Parkinson’s.
They have also proven their aptitude in the treatments for heart disease, permitting patients to fundamentally grow their own bypass.
Stem cells have the ability to help treat several life-threatening sicknesses like leukemia, non-Hodgkin’s lymphoma, anemia, inherited sicknesses and all other scarcities of the immune system.
Lifestyle ailments such as diabetes, liver disorders and heart sicknesses can also be treated with stem cells.

On the other hand, a broader variety of recipients can profit from cord blood stem cells. These can be stowed and uprooted back into the donor, to a family member or to an unconnected recipient. For bone marrow transplantation, there must be a virtually picture-perfect match of certain tissue proteins between the donor and the receiver. When stem cells from cord blood are employed, the donor cells seem more likely to take or engraft, even when there are fractional tissue disparities. Certain difficulties like graft versus host disease (GVHD), in which donor cells can attack the receiver’s tissues, are less likely to happen with cord blood than with bone marrow. This might be because cord blood has a subdued immune system and certain cells, typically active in an immune reaction, are not yet accomplished to attack the recipient. A research done in this arena publicized that kids who received a cord blood transplant from a closely coordinated sibling were 59 percent less likely to develop GVHD than kids who got a bone marrow transplant from a closely coordinated sibling. Cord blood also is less likely to encompass certain contagious agents, like some infections, that can pose a risk to transplant receivers. Furthermore, cord blood might have a bigger aptitude to generate new blood cells than bone marrow. Ounce for ounce, there are approximately 10 times as many blood-producing cells in cord blood. This fact advocates that a smaller number of cord blood cells are required for a fruitful transplantation.

What diseases can stem cells cure?

Umbilical cord blood is an opulent source of stem cells. These cells are the specialized cells that are able to segregate into other varieties of cells. They also have the aptitude to substitute affected cells with new cells. For this reason, cord blood stem cells have been used in countless transplants, where patients necessitate re growth of cells by substituting the affected ones. In this blog, we have seen how cord blood cells are being used to treat numerous lung and kidney sicknesses. By steering the transplant with cord blood stem cells, the researchers were able to treat the air route in lungs, impaired after an injury. This was a key breakthrough in the history of medical research and would be useful to perceive and comprehend diverse categories of lung diseases. Also, the scientists would now have the aptitude to test diverse drugs to treat the ailments and measure their effects on patients. The research exhibited that these cells were also useful to treat lung sicknesses like cystic fibrosis in infants with their own cord blood stem cells. In addition to that, the new development in the arena of stem cells also warrants better understanding in lung diseases and diverse periods of lung development.

With the speedy advancement in medical science, there has also been an equivalent development in the quantity of preserved cord blood units being used in regenerative medicine applications. If expectant parents stockpile their baby’s cord blood in a family bank, the stem cells are instantaneously available for usage in medical treatments, including forthcoming therapies to overhaul or replace impaired heart tissues. Consequently, a baby’s cord blood could prove to be a life-saving treatment alternative if that child is born with an inborn heart defect, or later in life following an abrupt and serious heart attack. In regenerative medicine, the newest scientific evidence recommends that using one’s own stem cells likely delivers more promising outcomes. The procedure of finding and developing new medicines is long and expensive. It takes years and billions of rupees for one single new drug to be developed from the period in which a contender molecule was recognized to the ultimate stage of regulatory sanction for marketing. The new age of stem cells and regenerative medicine does not abbreviate this procedure. In contrast, it presents new challenges in the way via translation into approved therapy. The challenges are because of the totally new and different structure of the final invention. Patients are treated with living cells rather than active molecules. The path to develop new cell based therapy is not less lengthy, intricate or exorbitant than the road to develop traditional medicines.

What are the Side-Effects of Stem Cell Therapy and How can you Tackle Them?

Posted On November 26, 2018 By stemcellcareindia Stem Cell Care / No Comments

Stem cells are manufactured in the bone marrow of our bodies. They have the amazing potential to develop into several diverse cell varieties. Serving as a kind of repair system for the body, they can theoretically split without limit to restock other cells. When a stem cell splits, every new cell has the potential to either remain a stem cell or become another kind of cell with a more specialized function, such as a muscle cell or a red blood cell. Stem cells have the aptitude to regenerate any other cell of the body. Therefore, a stem cell can become a neuron, a liver cell, a brain cell, a fingernail cell, or any other cell that has to be substituted or mended. Since long, researchers have tried to harness the power of stem cell therapy for the advantage of human race and considerably they have been prosperous in some facets. However, the path to finding a complete cure for degenerative sicknesses is awash with challenges. With the potential that stem cells have, they bring along several risks and investigators are very well alert of these risks, so they now aim to cut the risk factors and develop safe processes for stem cell therapy. To justify the promise of stem cells, they are now finding ways of confronting the risks related with them.

The major related complications

Understanding the complications linked to stem cell therapy is essential for success of such therapy. Notwithstanding of some of the complications that scientists perceived during administration of stem cell therapies, majority of the cases shows encouraging outcomes. Countless scientists use adult cells including those reaped from fat tissues, which flow in diverse body parts after being vaccinated in a patient. Out of all the varied cell categories that researchers use, embryonic cells have enticed most of the controversy owing to the ethical problems related to them. However, stem cell therapy advanced further with the unearthing of other sources of stem cells.

What are the side effects of stem cell therapy?

Side-effects from astem cell transplant before the transplant, you will be given chemotherapy, which might or might not be combined with radiation therapy. Consequently, maximum of the side effects of this therapy are like the side-effects that chemo and radiotherapy can leave. These side effects generally result in the risk of infections. Infections are the most common side-effect. Cancer treatments deteriorate the body and the immune system. This makes the body susceptible to infections from viruses, bacteria and other microorganisms. The patient is at uppermost risk during the early weeks after the transplant. Other common side-effects that point up instantaneously include:

Mouth sores
Fatigue
Low levels of red blood cells, which results in anaemia
Sharp drop in platelet count, which can also reduce the capacity of blood to clot
Diarrhoea

Long-standing side effects from transplant which can develop from some months to years after the therapy are:

Infertility
Hazard of developing another cancer
Cataracts
Thyroid complications
Early menopause for females
Lung or bone mutilation

Handling the complexities

To dispose of the obstacle of mining embryonic stem cells, scientists came up with induced pluripotent cells, which are just like embryonic cells and can be made in lab condition too. In some of the trials where induced pluripotent cells have been employed, patients have displayed no complications even after sometime of the treatment. It is, however, imperative to caution the patients about the complications before they go through stem cell therapy. Such therapies can lead to possible side-effects like weakness and exhaustion and in some cases it can result in nausea and signs of flu.

Usage of drugs to control the problems

In some circumstances, particularly in the treatment of cancer, patients have to undergo radiation and chemotherapy, as these are a part of transplant process. Doctors now try to control these impediments by recommending medications to manage the obstacles. Drugs for averting viral and fungal infections and for rapid immune system development are given to the patient after undergoing stem cell therapy. One of the most common intricacies is the attack of freshly formed blood cells on your stem cells. This ensues when the cells are derived from a donor. Using cells from the patient only is one of the effectual ways of handling this problem. Mesenchymal cells have been able to blow away this problem and other therapies are also administered accompanied by stem cell therapy to cut down immune reaction after getting cells from a donor.

Stem cell therapy seems to be more intricate than anticipated

Stem cell functions and biology is more intricate than what scientists thought and with every new investigation, a new optimism accompanied by a new hurdle comes to the surface. Experts now are working on reprogramming adult cells to make them work like embryonic cells. The deficiency of standardized approaches for stem cell therapy is another issue with the development of this treatment. Diverse individuals use diverse approaches for extracting reprogrammed cells and then scrutinizing them. This deficiency of uniformity also stands as a hurdle for proliferation of stem cell therapy. This is the reason why efficiency and security of these therapies are still under doubt. Refusal of the cells received from a donor by the patient’s immune system is another obstacle to watch out for and to circumvent this complication; doctors prefer the usage of mesenchymal cells, which have immune suppressive features, making it more desirable for cell transplantation. So, don’t hold your gasp for embryonic stem cell research to develop the antidote for Alzheimer’s or anything else. That just ain’t going to happen. Help your body create all of the stem cells required to maintain and overhaul itself with suitable nutritional support. Remember to move your body, eat well, supplement intelligently, drink lots of clean, drinkable and enhanced water and support your body’s natural aptitude to produce the stem cells essential to maintain and overhaul itself while it continues to move you toward health and well-being.

All About the Low-Cost Stem Cell Therapy that you Can Avail in India

Posted On November 17, 2018 By stemcellcareindia Stem Cell Care / No Comments

Research on low cost stem cell therapy India is ongoing and each day a new fact emerges regarding the biology and functions of stem cells and how these can be applied remedially for treating diverse degenerative diseases. Transplantation of cells for overhauling incapacitated organs and restoring impaired tissues puts forward a very encouraging exemplar for treatment of speckled sicknesses and if proven totally safe, then this can finish off the expensive organ transplantation operation, which is the solitary treatment choice for patients struggling from illnesses such as arthritis, liver cirrhosis and other such ailments. Stem cell therapy is conceivable owing to the competence of repopulating of stem cells via trans-differentiation and differentiation.The usage of stem cells for curing severe medicine is a progressive division of regenerative medical treatment with the aim to reinstate organ and tissue function for patients with a number of illnesses and progressive ailments.

How it works?

It releases factors that have a curative and regenerative influence on impaired tissues.
It creates angiogenesis or upsurges the blood supply in impaired tissues which leads to their reparation.
It substitutes the impaired cells of the tissue with healthy ones, therefore turning non-operational tissues into operative ones.

Stem cell varieties and benefits

Stem cells can go through both differentiation and self-renewal. These cells are found in numerous matured mammalian tissues, but adult cells may be developed into some cell varieties only. While, embryonic cells, mined from premature mammalian embryos comes with the competence of forming any type of differentiated cell of human body. Another benefit of embryonic cells is that these have typical karyo type while retaining high level of telomerase activity as well as exhibiting long-standing possibility of proliferation. This makes unbounded expansion conceivable in culture. When conveyed to vivo environment, these cells are able to segregate to side-shoots of the three sheets of embryonic germs.

Novel developments in the expanse of stem cells

Some of the latest studies have also revealed the possibility of instigating lineage-specific differentiation of embryonic stem cells in vitro. Another emergent facet of stem cell treatment is the usage of mesenchymal cells for administering stem cell therapy. These are multipotent cells, and these can create both non-mesenchymal and mesenchymal tissues in vivo and in vitro. Although, diversity competence of these cells in vitro is well acknowledged, yet more info regarding biology and circulation in human beings is still required.

What are the types of stem cell treatment?

Following are the chief categories of stem cell treatment:

Allogenic stem cell therapy: This therapy employs donated stem cells. One drawback of this therapy is that numerous cases of these donated stem cells may be forbidden by the recipient’s body for immunity reasons. Furthermore, this technique of stem cell therapy is not lawful in India.
Autologo us stem cell therapy: This therapy uses the patient’s own stem cells that are gotten from the bone marrow and blood.

How is stem cell treatment performed?

Stem cell treatment is implemented in the following steps:

At the outset, the patient’s physical inspection is done to check whether he is in a state to accept a transplant. Numerous tests are conducted on the important organs of the patient like heart, liver and lungs to guarantee that his body is equipped to accept the transplant.
The reaping of stemcells is done. This procedure remains the same without any regard of the kind of transplant. The reaping of cells is done under the effect of general anesthesia. In this process, a needle is inserted into the crater of the rear hip bone and the bone marrow is gathered.
The patient’s body is made ready for the transplant. This embraces chemotherapy and radiation therapy to kill tumorous cancers and make room for the new cells.
Transplantation of stem cells is done after 1-2 days of chemotherapy and radiation therapy. In this procedure the bone marrow is infused intravenously in the similar way as any other product of the blood is offered. The health state of the patient is inspected for any indications of chest pains, cough and cold including fever.

Recent research and studies

On one hand where research is going on meticulously to develop safe stem cell treatment possibilities, steps to control the aptitude of self-renewal is also necessary on the other hand. Only a blend of both the facets can transfer stem cell therapy to the clinics. Presently, clinical investigation has gone to a very progressive stage where stem cells are being used as inoculations to prevent as well as manage incapacitating ailments. Stem cell culture including embryonic cells and induced pluripotent cells now offers likelihood to comprehend and study psychophysiology and molecular basis of cancer, diabetes, liver failure, heart sicknesses and countless illnesses of the nervous system.Recent advancement in the expanse of iPSCs has opened the gate of prospects in tissue engineering and regeneration. Now, stem cells of particular patients can be derived from adult cells, which can then restore into organ and tissues required. Prominent research institutes now takes benefit of all the progressions in the arena of stem cell treatment and is equipped with a variety of stem cell based therapies. It makes Cortina that patients can profit from stem cell therapy using varied methods and procedures. They are making every imaginable contribution in reconnoitering the potential of stem cell therapy and guarantee that patients can get a new optimism to live a healthy life. Low cost stem cell therapy India is used for a variety of sicknesses, ailments and injuries that have no other prospective treatment options. The severe neurological disorders that can be profited from stem cell therapy consist of autism, cerebral palsy, head injuries, mental retardation, muscular dystrophy, paralysis, stroke, spinal cord injuries, motor neuron disorders, etc. At Stem Cell Care India, we have the essential tools and equipment to perform treatments with extreme proficiency. We endeavor to offer the superlative outcomes of stem cell treatment to patients and help them return to a healthy life.

Want to Look Young Again? Opt for Stem Cell Treatment!

Posted On November 9, 2018 By stemcellcareindia Stem Cell Care / No Comments

When physical changes befall, it refers to the course of aging. It is one the natural occurrence and bitter veracity. Some of the signs of aging are balding, grey hair, wrinkles, memory loss, frail eyesight, mental weakening and hearing loss, etc.Several of those who try to find stem cell treatments for themselves or for a loved one do it owing to either a disease or injury has caused perpetual impairment of some sort. These treatments have the aptitude to both change a disease and its effects on the patient as well as the aptitude to reduce the suffering that the patient might be experiencing. Stem cell treatments are so prevalent owing to the aptitude that these cells know how to self-renew. It is extensively believed that one day as these treatments will become so progressive that via this treatment,illnesses such as cancer, Parkinson’s disease, Huntington’s disease and diabetes can all be treated as well as a swarm of other disorders. Stem cell treatments are one of the safest forms of treatment owing to the aptitude that these cells have to self-renew; it is this aptitude that gives them the potential to make tissues that can replace both impaired and sickly tissues within the body without carrying any hazard of negative side-effects as well as conceivable rejection. A remarkable number of individuals look for stem cell treatments in foreign nations because each nation has its own way of research as well as diverse precincts placed on both the research as well as treatment.

The reason that precincts on both stem cell treatments and research are in place around the world is owing to the controversy that is presently surrounding the usage of embryonic cells. The controversy is regarding the fact that often times the blastocyst is demolished. The blastocyst encompasses the embryo blast, which forms the embryo. Countless individuals object to the demolition centered on their own personal philosophical, moral or religious principles. They believe that alternate sources should be used. The alternate sources that are accessible for the use of stem cell treatments encompass the usage of milky teeth cells; genetic stimuli cue skin cells, umbilical cord blood or bone marrow. For many notwithstanding the controversy and cost of stem cell treatments, it is considered with the top regard. Progressively more families are traveling overseas in order for one of their members to get stem cell treatments that wind up improving their quality of life.

Is stem cell treatment expensive?

Although a prodigious number of stem cell treatments are in being many of them are still considered to be investigational and/or considered to be too expensive. This is another reason that these treatments are often tough to get, which then causes countless individuals to look away from their home nations for other feasible options, when seeking out these treatments.The science of anti-aging has progressed considerably over the past some years and the more the scientists learn, the more they are vouching for the usage of stem cells to take out wrinkles and delete the signs of aging. Specialists have learned that treating wrinkles and staining at the cellular level is the finest way to fight the signs of aging and consequentlya coupe of elite wrinkle and eye creams have started using stem cells. While stem cells are not the solitary way to treat wrinkles on the lowest levels of your skin, they have verified to reduce the time it takes to totally heal wrinkles. While surgeons and scientists are making daring claims that stem cells are the superlative way to treat and heal crinkles, only a select few creams are essentially using them. This pleads the question, just how imperative are stem cells for anti-aging?To answer the query directly, they are contributory in the treatment, and by far the most remarkable element that exists in the science of anti-aging. Initially discovered as a remedy for burn victims, stem cells have proven to upsurge the regeneration rate as well as exceed the rapidity with which skin cells are grown by 300%. It is these two aspects that is leading to all of the enthusiasm regarding the usage of stem cells in wrinkle or eye creams. To comprehend how stem cells straightaway affect the healing of wrinkles, we must first comprehend what a wrinkle is and how they are cured. A wrinkle is nothing more than a wound to your skin. Just like a cut or a scrape, it is a wound that to requires having skin grown to close and heal the wound. While it might not be as damaging as a wound that has totally cut the skin, it is momentous enough that it is challenging for your skin to heal by itself as you age. The reason that wrinkles appear on our skin when we grow older as contrasting to when we are younger boils down to the rate at which our skin renews and the rapidity at which we grow new skin.

We grow new skin cells and renew, quite simply, by our skin cells separating, crafting two cells where there was only one. The issue is that a skin cell can only split a certain number of times. Consequently, as we age, we have less skin cells available to split and the procedure is decelerated considerably leaving wrinkles on our skin. The more crinkles we have, the more our regenerative resources are overstretched, and the less effective the natural healing procedure becomes.Before maximum stem cell treatments can become a more genuine option, they need to clear from the investigational stage that they are presently in. For this to ,ensue more research must be done on both the conduct of these cells as well as the conduct of the diverse diseases and sicknesses that doctor’s believe can be treated via the different forms of stem cell treatments.Usher in the future of anti-aging at present and start using stem cell therapy today.

Is Stem Cell Therapy Safe to Cure Mental Retardation Patients?

Posted On October 30, 2018 By stemcellcareindia Stem Cell Care / No Comments

The neuro-developmental disorder can have a harsh effect on a kid’s life. Mental retardation is an ailment which causes widespread consequences. It is well-defined as a condition in which the kid has an inadequate or a restricted mental growth that leads to impaired skills and intelligence. Mental retardation results in the child exhibiting a below-average performance that causes complications to communicate, interact publicly, be self-sufficient, lack in manners, etc., which might affect the kid’s overall safety and health. The neuro-developmental ailment is classified into four diverse categories:

Mild
Moderate
Severe
Profound

What causes mental retardation?

Any disorder which impedes the normal development of the brain, before or after birth, can lead to symptoms of mental retardation. Some of the recognized risk factors that cause mental retardation are stated below:

Infections during or after birth
Hereditary complaints (X Syndrome, Down Syndrome, etc.)
Unreasonably high bilirubin levels in babies
Intrauterine exposure to toxic materials (hard medicines or drugs and alcohol during pregnancy)
Malnourishment during pregnancy
Trauma or serious early infantile disorders
Environmental elements (mercury/lead poisoning)

The signs and symptoms of mental retardation

The commonly perceived symptoms perceived in a child affected with mental retardation are:

Incapacity to focus or pay attention
Memory difficulty
Postponement in oral language development
Restricted motor coordination
Trouble with problem-solving and logical thinking
Trouble in understanding their social role
Incapability to control behavior and emotions

Overall, the kid affected with mental retardation is slow to learn average activities and might need supervision and help to implement their everyday activities.

How is mental retardation treated?

Mental retardation cannot be treated totally with conventional treatment techniques. There are numerous therapies that are effective in assisting the kid and his/her family to adapt to the conditions and help improve the life of the kid. Stem cell treatment for mental retardation is an encouraging treatment or therapy that can aid in improving the outcomes of conventional mental retardation treatment techniques. Licensed stem cell research and therapy centers in India are celebrated for the enormous services in formulating an effective treatment for mental retardation. Largely, the stem cell therapy for mental retardation works by encouraging the nervous system of the body inside to restore the missing connections and improve information processing.

How stem cell therapy for mental retardation works?

The stem cell therapy for mental retardation principally works to improve tissue regeneration. Stem cells are found in the bone marrow. These stem cells are obtained from the patient using a minimally invasive method. These cells, when vaccinated into the patients, travel to the brain for the retrieval procedure and develop into numerous imperative new cells needed for normal functioning. These stem cells work to overhaul the impaired nerve tissue with their tissue regeneration properties. The cells start to stimulate the nervous system that leads to considerably better communication, interaction and numerous intellectual abilities. Therefore, stem cell treatment for mental retardation aids to kick-start the hindered mental development and its linked functions for a better tomorrow. Stem cell therapy can treat kids and adults suffering from numerous medical disorders. It is a safe therapy with no side-effects.

Is stem cell therapy safe?

Stem cell therapy can help treat patients in the impeccable way in India where the methods used for treatment have become progressive. These methods are giving admirable outcomes that have displayed improvement in the conditions of patients. However, in spite of being methodically explored and still more research is going on, still very few individuals are accepting the therapy to be safe and effective. On the contrary, many people might have undergone stem cells therapy but are not found to be somewhat contented with the result. They should comprehend that stem cells treatments are still very specialized treatment choices and not general processes. Furthermore, these treatments should be implemented under control conditions and proficient guidance, as legitimated by the regulatory bodies of government. It is therefore, quite a vital step to choose a right treatment centre and treatment process, to get effective therapeutic benefits. Cord blood cells have the capability to treat several acute diseases, which did not have any appropriate treatments before. However, progressively more researchers are required to comprehend the diseases and how they spread and affect. Only then the scientists will be able to come to the eventual solution.

Stem cell therapy is now a domiciliary term. Countless individuals are already open to the idea of going in to this treatment. We hear this term universally used by doctors and specialty clinics that offer beauty enrichment and aesthetic facilities. You can even see beauty soaps, facial balms, body creams and the like which claim to have this renovating agents in them. Several years ago, folks would fear processes like breast augmentation, implant placement or liposuction. It is usual for individuals to have second thoughts or even dread what they are not acquainted with, particularly uncommon surgical techniques. But when several celebrities and legislators took the risk and had fruitful and superb results, the craze effect began. The same is factual with the dawn of stem cell therapy. The more the media droned about it, the more individuals wanted to test the procedure. So many folks around the globe are now looking in to this for the regeneration of their youth. The query is, is it safe? You have to comprehend first that this is not a cure-all remedy – regrettably it is not. The objective of this therapy is not a longevity-anti-aging program. This therapy is essentially trying to permit the body to heal itself. In other words, this treatment will help you reach your cosmetic or health objective quicker than when you just let your own body to do its work. So is it safe? Yes, quite safe! To add to your self-confidence, make certain that the medical crew in that clinic is comprised of professional, extremely experienced, and lengthily accomplished medical specialists and that all techniques are implemented by a well-esteemed team of doctors.

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