Which Clinic Provides The Best Stem Cell Treatment In India?

Posted On April 8, 2019 By stemcellcareindia Stem Cell Care / No Comments

What Are Stem Cells And How Can They Give You A Healthy Life At An Expert Hospital?

Several complications which lead to the deterioration of bones, cartilage, muscle and other varieties of tissues can be hazardous, and at times fatal, as they are progressive and have to be treated as timely as possible. Cells are the building slabs of the human body that form the tissues and organs. They serve diverse purposes and devise from simpler cells. These simpler cells are the stem cell which are specialized cells and replicate themselves to rejuvenate body tissues. They also have the aptitude to overhaul impaired portions of the body. The usage of stem cells for treating several medical conditions is a cutting-edge branch of regenerative medical treatment with the aim to reinstate organ and tissue function for patients with numerous illnesses and progressive ailments.

How it works?

It releases factors that have a curative and renewing impact on impaired tissues.
It creates angiogenesis or upsurges the blood supply in impaired tissues which leads to their overhaul.
It substitutes the impaired cells of the tissue with healthy ones, therefore converting non-functioning tissues into functioning ones.

Different types of stem cells used for treatment

Stem cell treatment in India is in its introductory stage. There are lots of queries regarding its efficacy and after-effects. First, it is vital to comprehend the sources of stem cells. There are three key sorts of stem cells:

Adult Stem Cells are found within particular tissues in our bodies which can refurbish themselves or generate new cell that can replenish deceased or impaired tissues. The impaired cells are substituted with healthy ones via stem cell treatment.
Umbilical Cord Stem Cells are attained from the blood of the umbilical cord if conserved at birth. This is an opulent source of stem cells that can be used for the treatment of voluminous blood and immune system ailments.
Embryonic Stem Cells are gained from the embryos at a developing phase before they are implanted in the uterus. They are gotten from the additional embryos from IVF clinics.

Stem cell treatment benefits

Stem cell treatment can be used as effective treatment decorum to cure severe ailments like cancer. Wonder how? Patients with cancer might be treated with chemotherapy or radiotherapy. However, because of such treatment methods, in maximum circumstances, healthy cells also get slaughtered. Now, with the advantage of the stem cell treatment in India, it can permit restoration of stem cells that could have been demolished or annihilated. Henceforth, the patient who has undergone a transplant is able to take on with therapies such as chemotherapy or radiotherapy. In a majority of circumstances, bone marrow is often impaired as a result of high-dose treatments. Because of this damage, the concerned person is not able to produce blood cells in a generous amount that are accountable for conveying oxygen to the varied portions of the body so as to inhibit the snowballing rate of hazards or difficulties like bleeding and infection. Stem cell transplantation can be used to treat leukemia and lymphoma. Also, it can be used to treat cancers such as neuroblastoma, multiple myeloma, etc.

Diseases and disorders that can be treated with stem cells

Stem cell treatment in India is used for an array of disorders, syndromes and injuries that have no other prospective treatment choices. The severe neurological ailments that can be profited from stem cell therapy consist of autism, cerebral palsy, muscular dystrophy, mental retardation, paralysis, stroke, head injuries, spinal cord injuries, motor neuron disorders and the list is quite long.

Significance of cord blood transplantation

Doctors in India contemplate cord blood transplantation as an alternate to bone marrow transplants presently. The sources of such transplants are umbilical cord blood, peripheral blood and bone marrow; they aid in forming blood cells. Such treatments can be used to treat a catholic array of sicknesses entirely. Henceforth, going for a stem cell transplant is favored by a majority of patients and surgeons both. Now, with the assistance of the stem cell treatment in India, you can encounter reinstatement of stem cells that could have been demolished or destroyed because of chemotherapy or radiotherapy.

Which clinic provides the best stem cell treatment in India

If you ask which clinic provides the best stem cell treatment in India, there are lots of clinic having vast teams of professional surgeons, specialists and healthcare professionals who comprehend the variable prerequisites of every patient. Just like no two persons are the same, treatment and recovery choices vary from individual to individual. Choose a clinic whose objective is to find the most suited treatment for you and ensure the best of care. Make sure to choose the clinic or hospital like Max hospital in Delhi as it has the essential tools and equipment to execute treatments with utmost efficiency. It aims to offer the finest results of stem cell treatment to patients and support them to recoup a healthy life.

Stem Cell Transplant Liver Complications

Posted On March 25, 2019 By stemcellcareindia Liver / No Comments

The Myriad Of Complications That Can Arise After Stem Cell Liver Treatments

Liver is a vital organ in a human body and has very significant responsibility to keep the body clear from contaminants. It works as a filter, besides doing other very imperative metabolical actions. The cells of liver, medically identified as hepatic cells, have fantastic capability to regenerate or regain normality, if inflamed or incapacitated by any external assault of toxins, pathogens or chemical reagents. But persistent and constant exposure to such detrimental agents make the hepatic cells lose its original properties and become irrevocably sick.

Cirrhosis of liver is a chronic sickness which is degenerative in nature. In cirrhosis, the usual hepatic cells are impaired beyond repair and are substituted by scar tissues. Cirrhosis is a term used for a late phase of fibrosis of liver. This blemishing of liver cells might be because of liver diseases or other liver disorders. Viral infections such as hepatitis and chronic ingestion and abuse of alcohol are such causative factors of cirrhosis of liver. Cirrhosis of Liver has been professed as an irredeemable disease. The mutilating or fibrosis which has befallen in the hepatic tissues cannot be overhauled under any condition. But there are treatments and medications found effective to either delay or avert further impairment of liver cell those are still healthy. This encompasses several approaches, such as change in patient’s lifestyles, very careful diet, appropriate medicine, complete physical rest and regular consultation and strict administration of the treating doctor. It takes a quite long time of continual therapy to control and avert further impairment of liver cells in a patient of Cirrhosis of Liver. In some circumstances of unforeseen complications, operation is performed on cirrhosis of liver patient to manage and control the situation.

Stem cell therapy for liver cirrhosis

Stem cell therapy is resettling some stem cells in the affected portion of the body. Stem cells are undifferentiated cells which can segregate and regenerate into many specialized cell varieties required in diverse portions of the body. A theory of stem cell regeneration in impaired liver cells has been considered as most effective in upgrading the misplaced hepatic cells. Stem cells can rejuvenate into hepatic cells and take over the role of liver cells which were lost because of fibrosis. Liver cells are multi functional biologically. It is accountable for digestion, blood sugar control, blood clotting, transportation of fat, cholesterol, growth of red blood corpuscles and also for elimination of contaminants and metabolic wastes from blood. The most favored stem cells for transplant in a patient of Cirrhosis of Liver are Autologous Adipose Tissues. The patient him/herself is the donor of stem cells those are to be relocated into the affected portion of Liver. These stem cells are without any jeopardy of rejection as they come from the patient him/herself. After transplantation in the affected portions of the disfigured liver, these stem cells trans-differentiate into hepatocytes. They also create soluble factors those encourage regeneration and repair of hepatic cells. This is still the most effective stem cell treatment for cirrhosis of liver.

Stem cell transplant liver complications

Liver disease is common post hematopoietic stem cell transplantation. Stem cell transplant liver complications that are not directly drug-tempted include graft-versus-host disease, fungal liver disease, viral hepatitis, cholestasis of sepsis, and liver injury as a consequence of total par enteral nutrition. Having a stem cell transplant is a chief challenge for your body. As you recuperate in the first weeks and months, you are likely to feel drained and weak. Certain side effects like flu symptoms, nausea and an altered sense of taste, are common. Try to be persistent: You are building a brand-new immune system and this will definitely take some time. Your doctors will observe you watchfully and give you medicines to avert any further difficulties. Accompanied by these typical side effects, you might experience complications. Some originate from the high-dose chemotherapy and radiation that might be part of the transplant procedure. (These might be less likely if you have had a mini-transplant with low-dose chemotherapy and radiation.) Other problems are instigated by your body’s efforts to reject donor stem cells.

Complications from transplants using your own stem cells

The most common difficulties are:

bleeding and anemia
infections
interstitial pneumonia (swelling of the tissue that supports the lungs)
liver impairment and disease
dry and impaired mouth, esophagus, lungs and other organs

Less often, some patients also encounter cataracts, infertility (if total-body radiation is given), and new, subordinate cancers, at times as long as a decade after the original cancer. There are a lot of ways your consultant can help you with these problems. Antibiotics, anti fungal medications and antiviral medicines can help avert and treat bacterial, fungal and viral infections. Growth factor medications will accelerate the development of your new immune system and transfusions might avoid or treat bleeding and anemia.

Stem Cell Therapy In India For Autism

Posted On March 15, 2019 By stemcellcareindia Autism / No Comments

What Is Autism And Can Stem Cells Play Significant Role In Treating This Disorder?

What is autism?

Autism is a band of illnesses characterized by noticeable abnormalities in communication and social interactions. Two common unfailing findings are related in kids with this disorder are reduced oxygenation in particular zones of the brain and a chronic immunologic ally mediated inflammatory situation in the gut.

What is the scientific justification behind using stem cells to cure autism?

Present investigative therapies for autism aim to reverse these aberrations via administration of antibiotics, anti‐inflammatory agents and hyperbaric oxygen. Regrettably, none of these methodologies address the root causes of oxygen deprivation and intestinal swelling. The justification behind treating autism with umbilical cord tissue-derived mesenchymal stem cells is that autism, and its gradation of severity, has been considerably correlated inflammatory and neuro-inflammatory cytokines including macrophage-derived chemokine (MDC) and thymus and activation-regulated chemokine (TARC). Intravenous administration of umbilical cord MSCs has been displayed in multiple clinical trials to decline swelling. Declining swelling in the autistic patient might assuage symptoms of autism.

What do we know about autism in detail?

Autism is the name used to designate a range of neuro developmental ailments that damagingly affect brain development and cause life-long shortfalls in communication, social and behavioral skills. There are four ailments that fall below the integrated heading of autism spectrum disorder (ASD): autism (also referred to as classical autism), Asperger’s disorder, childhood disintegrative disorder and pervasive developmental disorder not otherwise quantified. Kids with autism appear normal at birth, but within the first 36 months symptoms begin to appear. Boys are four times more vulnerable than girls. There is no single assessment to identify autism. Rather, health specialists use physical investigations, personal histories, clinical assessment tools and perhaps hereditary testing to make a positive diagnosis. The exact reason of ASD remains a mystery but increasing evidence points to both environmental and hereditary factors. The risk of getting ASD is 37-90% but there are also several mutations related with ASD that might be present in a family member for the first time. Scientists have acknowledged chromosomal aberrations and single gene disorders that share symptoms with ASD and hundreds of ASD-linked genes that they think may confer vulnerability. Researchers are aiming to comprehend how ASD-linked genes work. Some of the genes are identified to connect neurons in the brain and others are involved in the immune system. One theory is that the brain might develop atypically if ASD-linked genes are active at the incorrect time and place as the fetus develops. Treatments can be behavioral, nutritional and pharmacological. Behavioral intrusions and social skills training seem to offer the maximum advantage but they are not able to rectify all the symptoms, so medications are also recommended.

How can stem cells play their role?

Presently, the field isn’t ready to utilize stem cells as a source of neurons for transplantation into patients with autism. Rather, stem cells are being used to make models of autism for the purpose of analyzing the effects of possible newfangled drugs. Scientists are also examining how the immune system and inflammation are involved in the growth of ASD, and whether stem cell therapy in India for autism could help play a role by checking the immune system in patients.

Are there lots of groups working on developing a stem cell therapy?

There are countless research crews around the world working to comprehend how stem cells could be applied to autism. Jointly, these groups have acknowledged making human models of autism a priority as animal models do not completely mimic autism as it unfolds in humans. One of the challenges is finding a worthy source of neurons for the purpose of forming laboratory models. This is not so simple because it is not possible to eliminate neurons from a living individual. This is where induced pluripotent stem (iPS) cells might be able to assist. Their discovery in 2006 was nothing but a revolutionary invention. Doctor who carried out that research managed to fold back the clock on adult skin cells and reprogram (induce) them to a more young-looking state. The cells are called ‘pluripotent’ because they are no longer sealed into making only one kind of cell but rather can make a multiplicity of diverse varieties of cells, including neurons. The iPS cells made from the skin of individuals with autism can be grown into neurons for laboratory models.

The street to finding a stem cell therapy for autism is cemented with several challenges that will take time to overcome, but researchers are learning a lot from scrutinizing autism spectrum disorders and disorders that share features with autism, such as Rett syndrome, Fragile X and Timothy syndrome. As the joint outcomes shed light on potential mechanisms of autism, they also emphasize the exclusivity of autism from individual to individual and the challenges of capturing the catholic spectrum of autism in human models.

Stem Cell Bone Marrow Transplant In Delhi

Posted On March 7, 2019 By stemcellcareindia bone marrow transplant / No Comments

The Detailed Guide Of Stem Cell Bone Marrow Transplant

A stem cell transplant can be referred to as a bone marrow transplant (BMT) or peripheral blood stem cell transplant (PBSCT) or umbilical cord blood transplantation (UCBT), contingent on the source of the cells that are uprooted. In other words, the solitary real distinction between a bone marrow transplant and a stem cell transplant in the technique of collecting the stem cells. Stem cells are versatile cells with the aptitude to split and develop into numerous other types of cells. Hematopoietic stem cells create red blood cells, which transport oxygen throughout the body; white blood cells, which help keep off infections; and platelets, which permit blood to clot and wounds to heal.

Stem cells for transplant can originate from the bone marrow or blood.
Stem cells for transplant can emanate from the bone marrow or blood.
Hematopoietic stem cells are found in the bone marrow—the malleable material inside the bones.
Some of the hematopoietic stem cells flow from the marrow into the bloodstream. When the cells are found there, they are named peripheral blood stem cells.

While chemotherapy and/or radiation therapy are vital treatments for the majority of cancer patients, high doses can sternly weaken and even obliterate healthy stem cells. That is where stem cell bone marrow transplant in Delhi comes in. When stem cells are reaped from bone marrow and transplanted into a patient, the process is known as a bone marrow transplant. If the uprooted stem cells came from the bloodstream, the process is called a peripheral blood stem cell transplant—at times shortened to “stem cell transplant.” Whether you hear somebody talking about a “stem cell transplant” or a “bone marrow transplant,” they are still mentioning stem cell transplantation. The solitary difference is where in the body the uprooted stem cells came from. The transplants themselves are the similar.

What is a bone marrow transplant (stem cell transplant)?

A bone marrow transplant, also named as stem cell transplant, is a treatment for some categories of cancer. For instance, you may have one if you have leukemia, multiple myeloma, or some kinds of lymphoma. Specialists also treat some blood ailments with stem cell transplants. Formerly, a stem cell transplant was more universally called a bone marrow transplant as the stem cells were gathered from the bone marrow. Nowadays, stem cells are generally collected from the blood, rather than the bone marrow. For this reason, they are now frequently called stem cell transplants.

Why are bone marrow and stem cells important?

A portion of your bones called “bone marrow” makes blood cells. Marrow is the soft, malleable tissue inside bones. It encompasses cells called hematopoietic stem cells. These cells can turn into numerous other varieties of cells. They can turn into more bone marrow cells. Or they can turn into any kind of blood cell. Certain cancers and other ailments keep hematopoietic stem cells from developing usually. If they are not normal, neither are the blood cells that they make. A stem cell transplant gives you novel stem cells. The novel stem cells can make new, fit blood cells.

Types of stem cell transplant

The key categories of stem cell transplants and other choices are discussed underneath:

Autologous transplant. This is also named an AUTO transplant or high-dose chemotherapy with autologous stem cell release. In an AUTO transplant, you get your own stem cells after surgeons treat the cancer. Firstly, your health care crew gathers stem cells from your blood and freezes them. Subsequently, you have powerful chemotherapy, and hardly, radiation therapy. Then, your healthcare crew defrosts your frozen stem cells. They put them back in your blood via a pipe placed in a vein (IV). It takes around 24 hours for your stem cells to reach the bone marrow. Then they begin to grow, multiply and aid the marrow to make healthy blood cells again.
Allogeneic transplantation. This is also named an ALLO transplant. In an ALLO transplant, you get another individual’s stem cells. It is imperative to find somebody whose bone marrow matches yours. This is because you have some proteins on your white blood cells named human leukocyte antigens (HLA). The finest donor has HLA proteins as much like yours as possible. A brother or sister might be the finest match. But another family member or volunteer might also work. Once you find a donor, you get chemotherapy with or without radiation therapy. Next, you get the other individual’s stem cells via a tube placed in a vein (IV). The cells in an ALLO transplant are not normally frozen. This way, your doctor can give you the cells as soon as possible after chemotherapy or radiation therapy. There are 2 kinds of ALLO transplants. The finest category for each person depends on his or her age, health, and the kind of ailment being treated. i.e. Ablative, which uses high-dose chemotherapy and reduced intensity, which uses minor doses of chemotherapy.
Umbilical cord blood transplant. This might be a choice if you cannot find a donor match. Cancer centers around the globe use cord blood.

How Long Can You Live After A Stem Cell Transplant

Posted On February 26, 2019 By stemcellcareindia Stem Cell Care / No Comments

Learn about the merits and benefits of stem cell transplant

The stem cell transplant is a method that uses the split-up and cleansing of autologous, allogeneic or xenogeneic stem cells to transplant to the body of patients, which can cure the linked ailments. This kind of transplant is to cure some varieties of cancer, leukemia and other ailments impacting the bone marrow. In recent years, the stem cell study has been a trendy topic in the bio medicine arena and it is considered as the advancing position in the life-science research, standing in the track of the life science research. The implication of the stem cell is to help decrease the pains from those illnesses and protract the patient’s life. When the patients have impaired or unhealthy stem cells, the healthy stem cells will be in the body by the infusion or inoculation. When the bone marrow stops working, the adequate healthy stem cells can’t be formed. At this moment, you have to accept the stem cell transplant. It is acknowledged that multiple myeloma is a cancer of the plasma cells that is converted into a malevolent cell and starts to grow irrepressibly. The dissection and the upsurge of the myeloma cells will lead to the patient in numerous ways. These cells will affect the body’s aptitude to build bone strangely and cause bones to deteriorate and break down.

The patients with this ailment will struggle with a condition called hypercalcemia linked with pain, nausea, vomiting, reformed mental states and depression. The uncharacteristic protein produced by myeloma cells will lead to the mutilation to the organs, particularly the kidneys. If untreated, you will lose your life to some degree. The stem cell transplant has been used extensively in the clinical treatment. Equating to the traditional treatments, the new therapies, stem cell transplantation has shown substantial improvements in response rates. Autologous transplant gives you back your standard bone marrow. When you decide to undergo the stem cell transplant, the first thing is to contemplate whether the hospital is the best. Nevertheless, not every hospital can implement transplants. It is essential to make sure whether the hospital which offers a veteran crew of specialists working closely with nurses, oncology pharmacists and a squad of transplant co-coordinators to offer multidisciplinary care to all patients. A prosperous transplant attribute to these aspects, including the profundity of experience, positive result and innovative research a knowledgeable crew of experts working closely with nurses, oncology pharmacists and a multidisciplinary crew. Consequently, before you select the hospital, you should take these aspects into account.

Stem cell transplants have become imperative weapons in the battle against certain blood cancers, such as multiple myeloma, non-Hodgkin’s lymphoma, Hodgkin lymphoma and leukemia. How long can you live after a stem cell transplant? A stem cell transplant might help you live longer. In some circumstances, it can even cure blood cancers. Almost 50,000 transplantation’s are executed annually, with the number snowballing 10% to 20% every year. More than 20,000 individuals have now lived five years or longer after having a stem cell transplant. Here is how it works: The stem cells in healthy bone marrow create blood cells, including the white blood cells that are vital for your immune system. Blood cancers themselves impair your bone marrow and so do chemotherapy and radiation treatments for the cancers. A stem cell transplant lets new stem cells take possession of from your impaired marrow so your body can yield healthy, cancer-free blood cells. Survival rates have amplified ominously amid patients who got blood stem cell transplants from both related and unrelated donors.

Your doctor might want to use stem cells taken from your own blood, or stem cells from a donor. If you utilize your own stem cells, your blood will be strained when your cancer is not active. If you use a donor’s cells, your doctor will first have to find a matching donor. Either way, you will have chemotherapy and/or radiation in advance. This will slaughter the cancer cells and terminate your impaired stem cells so the transplanted stem cells can take over. If you apply your own cells, you might be able to have an outpatient stem cell transplant. You need to have no other serious medical disorders, have a caregiver who can supervise you at home and live within an hour of the hospital. Your home atmosphere must be cautiously prepared and you should wear a mask when going out.

Retrieval from your stem cell transplant

You will feel exhausted for the first few weeks. It might be numerous months before you can recommence your normal schedule. Around two months after the transplant, your doctor will draw blood and might take a sample of bone marrow from your hip to see that you are generating all kinds of blood cells. The bone marrow will also show which cells are being formed, yours or, if possible, the donor’s. This is acknowledged as chimer ism. Your specialist will also want to see that you have no foremost complications.

Can Stem Cells Repair Traumatic Brain Injury

Posted On February 18, 2019 By stemcellcareindia Stem Cell Care / No Comments

Is Somebody Suffering From Traumatic Brain Injury? Stem Cell Might Help Them!

Traumatic brain injury (TBI) can cause a multiplicity of complications, health effects that are not TBI themselves but that consequence from it. The jeopardy of complications upsurges with the severity of the trauma; however even mild traumatic brain injury can lead to incapacities that interfere with social interactions, employment and routine living. As per the Brain Injury Association of America (BIAA), 1.7 million individuals suffer a traumatic brain injury each year in the U.S. Those who struggle with TBIs are more likely to labor under depression, nervousness, illnesses like Alzheimer’s and dementia, muscle coordination issues and other infirmities that might entail rehabilitation.

The symptoms of traumatic brain injury

The symptoms can differ from mild to moderate and even, contingent on the degree of mutilation done to the brains. An individual suffering from milder symptoms might experience unconsciousness for a couple of seconds or minutes or might remain cataleptic for a period of time.

The problems of traumatic brain injury

Problems of Traumatic Brain Injury are secondary conditions, symptoms, or other illnesses that are instigated by TBI. In many circumstances, the difference between symptoms of Traumatic Brain Injury and complications of Traumatic Brain Injury is vague or random. Some of the most common issues allied with traumatic brain injuries include the following:

Forfeiture of motor skills
Long or short term memory loss
Paraplegia or quadriplegia
Difficulty with senses (i.e. taste, touch, and smell)
Speech or understanding concerns
Seizures
Comas

The treatment of traumatic brain injury

Can stem cells repair traumatic brain injury? Yes! Stem cell treatment has marvelous benefits for traumatic brain injury sequelae, but maximum patients learn little about it. Presently, for TBI patients, there are three treatment approaches of stem cell treatment i.e. brain stereotaxis surgery, lumbar puncture subarachnoid space injection and intravenous infusion. The particular treatment depends on the patients’ conditions, and we typically contemplate amalgamation of 2 or 3 treatments, which takes benefits of every treatment and shows improved effects. Countless individuals with TBI have received the second, third even the fourth course of stem cell treatment, and every course shows a specific set of improvements.

Can stem cells repair traumatic brain injury?

There is lots of buzz about stem cells, but what are they and can they actually aid in reinstating health? In our bodies, adult stem cells are found in numerous regions such as muscles, skin, bone marrow and the brain. What makes them so valued is that unlike any other cell variety in the body, they can remain homogeneous for a lengthy time making more stem cells just like themselves. When the necessity ascends to overhaul or generate tissues, they become skillful of evolving into cells with specialized functions such as blood or nerve cells. In high traffic zones like the gut or skin, stem cells are constantly at work while in other locations such as the brain, other cellular elements are involved in triggering the regenerative response. The secretive ways in which stem cells function are not yet totally understood, but this has procreated a thrilling field of active scientific investigation. Regenerative medicine research has already established, however, that there is pronounced potential in the usage of stem cells as therapeutic associates in restorative treatments.

Each year, an estimated 2.5 million individuals in the United States sustain a traumatic brain injury, and TBI-related reasons contribute to a third (30.5%) of all injury-related demises in the United States. There are several diverse categories of traumatic brain injury including:

Concussions: The most common kind of TBI, well-defined as a head injury with fleeting disturbance in brain function (e.g. loss of consciousness, changed mental status).
Penetration injury: From bullets, shrapnel, and other stuffs entering the skull.
Contusions: Bleeding that arises from blows to the head.
Diffuse axonal injury: Brain injury from traumatic shearing forces happening with speedy acceleration or deceleration (e.g. motor vehicle mishap, shaken baby syndrome).

During traumatic brain injury, the impairment to brain tissues or interruption of blood supply to critical regions of the brain results in brain cell death. When the neurons die, they cannot redevelop or be replaced and the zones of the body they control become incapacitated. Traumatic brain injury (TBI) is a worldwide public health concern, with limited treatment alternatives obtainable. Notwithstanding improving survival rate after TBI, treatment is deficient for brain functional retrieval and structural reparation in clinic. Recent studies have recommended that the mature brain harbors neural stem cells which have regenerative capability following brain insults. Much growth has been made in pre clinical TBI model studies in understanding the behaviors, functions and regulatory contrivances of neural stem cells in the injured brain. Diverse approaches targeting this cell population have been evaluated in TBI models. In competition, cell transplantation approach using a catholic array of stem cells has been reconnoitered for TBI treatment in pre-clinical studies and some in clinical trials.

Can Stem Cells Help Kidney Disease Patients? Read On!

Posted On February 12, 2019 By stemcellcareindia Stem Cell Care / No Comments

Kidneys are the body’s waste disposal system, sieving our blood and vacuuming out all the waste products. Our kidneys have a restricted capability to help overhaul themselves but if somebody suffers from chronic kidney disease then their kidneys are gradually overwhelmed and that results in end-stage renal disease. At that point, the patient’s choices are restricted to dialysis or an organ transplant.

Chronic renal failure is an imperative clinical issue with substantial socioeconomic impact universally. Notwithstanding improvements in renal replacement therapies and organ transplantation, poor quality of life for dialysis patients and lengthy transplant waiting lists remain chief concerns for nephrologists treating this disorder. There is consequently a persistent requirement for innovative therapies to stimulate renal cellular repair and tissue remodeling. Over the last decade, progresses in the arena of regenerative medicine permitted development of cell therapies appropriate for kidney repair. Mesenchymal stem cells (MSCs) are undifferentiated cells that have immunomodulatory and tissue trophic attributes and the aptitude to segregate into numerous cell types. Studies in animal models of chronic renal failure have exposed an exceptional potential of these cells for improving function and regenerating the impaired kidney. Nonetheless, numerous limitations relating to insufficient engraftment, trouble to monitor and troublesome effects of MSCs remain to be addressed. Hostile effects observed following intravascular administration of MSCs consist of immune rejection, adipogenic differentiation, malevolent transformation and prothrombotic events. Nevertheless, maximum studies specify an amazing competence of MSCs to attain kidney repair. This review recapitulates the regenerative potential of MSCs to offer functional retrieval from renal failure, concentrating on their application and the present challenges facing clinical translation.

Mesenchymal stem cells (MSCs) can be isolated from a multiplicity of tissues, segregate into several cell lineages, and have unique immunomodulatory properties that enhance inflammation and immune responses, instituting a promising tool to simplify renal repair. MSCs are well-defined by the incidence of plastic-adherent cells under standard culture conditions, capability to segregate into osteoblasts, adipocytes and chondroblasts in vitro, expression of usual surface markers (CD29, CD44, CD73, CD90, CD105, and CD166) and the deficiency of CD45, CD34, CD14 or CD11b, CD79α or CD19 and HLA-DR surface molecules [10]. In recent years, investigational studies have revealed the potential of MSCs to improve renal function in numerous models of CKD, and numerous clinical studies have specified their security and effectiveness in CKD. Nonetheless, numerous hurdles need to be addressed before clinical translation. This review recapitulates the existing state of MSC transplantation for CKD, concentrating on their mechanisms of renal repair, hitches and obstacles for clinical translation, and prospective methodologies to overcome them.

Why stem cells help with chronic kidney disease (CKD)

Can stem cells help kidney disease? Yeas! The therapeutic targets in nephrology are the decrease of injury, the postponement of progression, or renal replacement therapy comprising of either renal transplantation or dialysis. Lately, new therapeutic strategies for tissue repair have arisen and one of the most encouraging methodologies is the usage of stem cells to decrease injury in Chronic Kidney Disease (CKD). Mesenchymal Stem Cells (MSC), centered on their capability to segregate into several kinds of functional cells, and anti-inflammatory properties, has materialized as the principal contenders in treating Chronic Kidney Disease (CKD).

Chronic kidney disease complications

The major Chronic Kidney Disease complications consist of: severe fluid retention including in the lungs (pulmonary edema), cardiovascular ailments, weak bones and amplified frequency of fractures, impotence, central nervous system impediments and abrupt vicissitudes in blood electrolyte levels, particularly potassium, which would be life-threatening in some circumstances.

Stem cells are the humans bodies overhaul mechanism. Stem cells can segregate into any functional tissue cells. Kidney cells necrosis and/or decreased kidney functions can be seen in uncharacteristic creatinine levels. The approved stem cell transplants for renal failure aid to restock the required kidney cells and thus encourage a more normal healthy kidney function. There are two categories of stem cells treatments that might be used in the regenerative protocols for renal failure using stem cells. One part of treatment is concentrated on promoting appropriate kidney function and the other would be to restock red blood cell amounts to help reverse the decline in HGB level. The autologous mesenchymal cells are transfused back into your body via a simple blood transfusion that permits the flowing stem cells could to reach the kidneys through normal blood circulation. This revolutionary treatment for renal failure can be done with and without dialysis and demands no surgical procedure that necessitates lengthy hospital stays only at the regeneration Center. The mesenchymal stem cell treatment for kidney ailment is done in several stages but every daily sitting takes about two hours every time.

Can Optic Nerve Hypoplasia Be Cured By Stem Cell Treatment?

Posted On February 6, 2019 By stemcellcareindia Stem Cell Care / No Comments

What is the optic nerve?

The optic nerve is an assortment of more than a million nerve fibers that convey visual signals from the eye to the brain. The optic nerve develops the first trimester of intrauterine life.

What is optic nerve hypoplasia?

Optic nerve hypoplasia (ONH) is a congenital condition in which the optic nerve is underdeveloped (small).

How is optic nerve hypoplasia detected?

The scrutiny of ONH is usually made by the appearance of trivial/pale optic nerve on ophthalmoscopic checkup of the eye. It is problematic to foresee visual acuity potential on the base of optic nerve appearance. Maximum cases of ONH have no evidently recognizable cause. There are no identified racial or socioeconomic aspects in the development of ONH, nor is there an identified association with exposure to pesticides.

What visual issues are linked with optic nerve hypoplasia?

Vision impairment from ONH ranges from mild to severe and might affect one or both eyes. Nystagmus (shaking of the eyes) might be seen with both unilateral and bilateral circumstances. The occurrence of strabismus is increased with ONH.

Is optic nerve hypoplasia linked with non-visual issues?

Optic nerve hypoplasia can be related with central nervous system (CNS) deformities which put the patient in danger for other issues, including seizure ailment and developmental postponement. Hormone insufficiencies befall in maximum youngsters, irrespective of associated midline brain aberrations or pituitary gland aberrations on MRI. In fact, maximum kids with growth hormone insufficiency have a normal MRI.

What tests should be done for kids with optic nerve hypoplasia?

An MRI scan is specified for all kids with optic nerve hypoplasia. Assessment by an endocrinologist should be obligatory for all patients under five years of age.

Does optic nerve hypoplasia get worse over time?

At large, ONH is a steady and non-progressive condition which does not worsen. Vision might improve marginally and nystagmus might decline over time.

Diagnosis of ONH explained in detail

Diagnosis of ONH is chiefly clinical. Currently, laboratory or radiographic inspections to establish the diagnosis of ONH are non-existent. ONH diagnosis is via ophthalmic substantiation of a trivial optic disc that is pale or grayish. The disc dimensions are measured by taking the distance from the optic nerve to the macula. ONH might also be accompanied by meandering retinal vessels that might affect both venules and arterioles. Otherwise, the vessels may be remarkably straight with abridged branching. However, in mild circumstances of ONH, the double ring sign may not be seen and the optical disc appears normal. Consequently, MRI of the intracranial visual pathways is an improved clinical diagnostic tool.

Reasons and risk factors

There is no identified reason of ONH. However, in several cases, numerous risk factors have been linked with ONH. These consist of maternal diabetes, maternal alcohol abuse and usage of anti-epileptic drugs. Others risk aspects include fetal or maternal infections such as Hepatitis B, young maternal age and preterm birth. Doctors are typically observant for any signs of hypothalamic dysfunction accompanied by any vision difficulties. For example, all kids with neonatal jaundice and recurrent hypoglycemia ought to have ophthalmoscopy examination, predominantly, if the kid experiences related temperature uncertainty. Furthermore, if a kid exhibits hormonal insufficiencies or inherited incongruity, MRI scan should be taken so as to identify intracranial abnormalities and rule out curable disorders. Growth of kids with ONH should also be scrutinized and their sexual development observed so as to forestall deferred sexual growth. They should also often undergo physical, occupational and speech therapy.

Is there any treatment for optic nerve hypoplasia?

There is nil medical or surgical treatment for ONH. However, obstruction of the better seeing eye might improve vision in the other eye. Kids with substantial vision loss in both eyes might profit from initial supportive attention by low vision experts. Stem cell treatment has not been revealed to be effective for ONH. Optic Nerve Hypoplasia (also recognized as ONH) is a condition that affects the optic nerves, which are accountable for conveying visual information between the eyes and brain. The occurrence of ONH as a chief reason of vision impairment has speedily been snowballing over the years. Individuals with ONH often experience visual sharpness, sensitivity to bright light, and outlying field loss. Consequently, they have woe recognizing faces and facial expressions. Moreover, they have challenges retrieving near and comprehensive information.

Could cell therapy treat optic nerve hypoplasia?

Can optic nerve hypoplasia be cured by stem cell treatment? Yes! There is hope for individuals living with optic nerve hypoplasia. Doctors have revealed that retrieving innovative cellular-based treatment can decelerate vision loss. Probabilities are that cell therapy could also offer new healing potentials as equated to traditional approaches of treatment. Widespread research on how live cell therapy can treat severe eye conditions is still continuing. For over a decade now, the cellular therapies have played a gigantic role in the treatment of ONH as the cells improve vision centered on their unique characteristics and variances.

Can Macular Degeneration be Cured with Stem Cells

Posted On January 26, 2019 By stemcellcareindia Muscular Dystrophy / No Comments

Macular degeneration is an ocular condition in which the central portion of the retina called the Macula breaks down occasioning in diminished vision. Generally, a genetic disposition is needed for the condition to befall and the severity will depend on both heredities and environmental aspects. Studies have long determined that aspects such as drug usage and smoking will precipitate the ailment to befall at earlier ages and will considerably make the vision worse. Smoking will upsurge the probability of the condition happening 300% and will also make it much worse than in a person that never smoked. There are also other less common kinds of macular degeneration, such as Sorsby’s disease, Best’s disease and Stargardt’s disease, which are genetic and can affect younger individuals. These are identified jointly as juvenile macular degenerative diseases. Extreme near-sightedness and other illnesses of the retina can also lead to the degeneration of the macula and while not to be muddled with age-related macular degeneration, can have the same end product of loss of central vision.

Dry Macular Degeneration

The “dry” or “atrophic” type of “macular degeneration” is typically recognized by yellowish deposits of debris in the retina. The material encompassing these deposits is generally carried away by the same blood vessels that carry nutrients to the retina. The success of this act appears to be lessened in circumstances of macular degeneration. There are numerous projected reasons for this including:

Insufficient blood circulation in the retina
Swelling
Premature aging of the sight cells because of hereditary deficiencies
Environmental aspects
Dietary aspects
Behavioral factors

One of the needs of your body for healthy life is Omega-3 fatty acids, something typically found in fish oils. A shortage of these oils can result in eye sicknesses, muscle weaknesses and skin issues, scratchy arms and legs and behavioral changes. Complementing your diet with a worthy source of Omega-3 will not only help improve your heart health and blood pressure but will be an advantage for your overall health and well being.

Macular degeneration treatments have improved in the last numerous years principally because this eye syndrome has become one of the principal reasons of blindness in individuals 50 years of age and older. With two types of the eye disease, macular degeneration that is referred to as the “wet” form of this eye ailment is treated with anti-VEGF drugs. These drugs such as Avastin and Lucentis are inoculated straight into the eye. Wet AMD is categorized by the formation of anomalous blood vessel growth as well as leakage. Treatments such as anti-VEGF drugs make the growth of these uncharacteristic blood vessels and the leakage paused. Wet AMD accounts for about 10 percent of the diagnosed circumstances, but leads to 90 percent of the sightlessness from this eye disease.

Dry macular degeneration befalls when drusen forms on the eye. This is the most common type of this eye disease, making for 90 percent of diagnosed cases and occasioning in only 10 percent of the sight lessness. There is no treatment for dry AMD but dietary supplements have been displayed to slow the evolution of this form of the eye disease. With the upsurge in the number of patients each year, research into new treatments for macular degeneration has become one of the fastest growth capacities. Research lingers and there have been sizeable advancements made in the anti-VEGF drugs as other pharmaceutical firms join the fight against this disease. Other researchers are reviewing drugs known as angiostatin corticosteroids, while others are reconnoitering more progressive forms of photo dynamic therapy. However, the most encouraging treatment for macular degeneration comes from innovation in using human stem cells. Can macular degeneration be cured with stem cells? Yes! Eye sicknesses such as ARMD damage the retina; particularly the eye disease impairs central vision. Human retinas impaired by this disease are inept to overhaul themselves. However, a report by researchers from the University of Washington recommends that the renaissance of impaired retinal cells might be possible using human stem cells. Using human embryonic stem cells and proteins to permit cell growth, researchers were able to grow cells that became progenitor cells for retinal cells. Inoculating these cells into an impaired mouse retina, these stem cells continued to develop into cones – retinal cells accountable for color. They also developed into rods – the cells that permit night vision. The stem cells also continued to develop into other retinal cells.

In summary, there are countless factors that can contribute to macular degeneration, but recent studies show that simple carbohydrates upsurge the probability of contracting and the severity of the condition. As with maximum ailments, eating the appropriate food will keep you healthier and avert some conditions. With this research, scientists hope to assess the nerve reactions and conclude if vision improved. If this proves to be efficacious, human tests using stem cells to overhaul retinas impaired by macular degeneration could befall within two or three years.

Learn About the Prime Significance of Stem Cell Therapy in India

Posted On December 22, 2018 By stemcellcareindia Stem Cell Care / No Comments

Stem cells are un-specialized or interchangeable cell of a multi cellular organism which is adept of giving upswing to indeterminately more similar variety of cells, certain other types of cell also ascends by differentiation via them and they take place of the impaired or lost cells. It plays a very fundamental role in body’s aptitude to renew and overhaul its tissues. From the above, following characteristics of stem cells can be cited: first, they are un-specialized that refurbish themselves for long periods through cell division. Second is that under some specific physiologic or investigational conditions, they can be induced to become cells with exceptional functions such as the beating cells of the heart muscle or the insulin manufacturing cells of the pancreas.

Why stem cell therapy is important?

The procedure of therapy or treatment with the assistance of stem cells is acknowledged as stem cell treatment. Research is ongoing to develop numerous sources for stem cells and to apply stem cell treatments for neurodegenerative diseases and disorders, diabetes, heart disease and other conditions. The most extensively used stem cell therapy is bone marrow transplant accompanied by therapies derived from umbilical cord blood. For over 30 years, bone-marrow has been used to treat cancer patients with disorders such as leukaemia and lymphoma; this is the solitary form of stem cell therapy that is extensively practiced. Stem cells are well-defined by their function in complex multidimensional environments called as stem cell niches. The simple site of stem cells is not enough to define a niche. The niche must have both anatomic and functional magnitudes, precisely permitting stem cells to replicate and self-renew. Adult stem cells usually have limited function without the niche. For instance, HSC, which renews the whole blood and immune system, circulate liberally, but seem to have little function outside particular anatomic locations. Chiefly, the research is going on with two types of stem cells. These are embryonic and adult. In addition to the overwhelming assurance of stem cells in numerous cellular therapies, their clinical and practical use is inhibited by numerous technical and ethical problems. The major hurdle for the clinical usage of adult stem cells is the trivial number of cells that can be isolated from any adult tissue. An outline of the prospective usage of stem cells for treatment of human disease is now traceable. The coming years will certainly inaugurate new developments and know-hows that would decode the projected therapeutic potential of stem cells to bedside medicine for patients struggling with distressing and incapacitating illnesses.

In the recent years, stem cells therapy has been evolving as the most viable option to treat variety of degenerative illnesses, which cannot be treated with the assistance of conventional treatment choices. Numerous clinical evidences have been amassed from gigantic obtain ability of data to assess the immense potential of stem cell therapy as a contemporary medicine. Various doctors are in this regard, supporting stem cell therapy in India; indicating it to be the most innovatory way to treat the root cause, with the assistance of body’s own restoring mechanism. Although, the therapeutic results are very promising, to affirm it to be the mainstream medicine; adequate clinical evidences are required, which can be gotten via huge variety of clinical trials. Thus, unquestionably, stem cells treatments are very auspicious and can prove as the prospective alternative for futuristic treatment arrangement, but are still modish for clinical applications. Stem cells are renowned to be the mother cells of our body, with the aptitude to segregate into numerous cells types, for the generation of whole cellular system. In fact, these are cells, which lay the sturdy foundation of internal metabolic paths and functioning aptitude of our body. This marvelous capability has been exploited by medical community to offer antidote to numerous diseases, ranging from spinal cord injury to mental retardation.

Technological progressions have permitted easy isolation of these stem cells from numerous sources of our body, such as bone marrow and adipose tissues. These cells are gathered from quantified sources outside the body, supplemented in the laboratory and are imbued back at the location of injury. A hefty fraction of isolated pool of stem cell is related with the existence of mesenchymal stem cells. Studies have publicized that these stem cells display sturdy anti-inflammatory properties to standardize immune system of the body. This widespread immune regulation is thought to be useful in creating an apt milieu for stem cells growth, development and differentiation. Furthermore, it has as well been predictable that mesenchymal stem cells show sturdy differentiation potential towards cells of varied lineages, like mesodermal, endodermal, ectodermal, etc. Thus, retrieval and effective therapeutic result, instantaneously after stem cells treatment can be accredited to production of appropriate micro environment for triggering resident stem cell to start a biological reaction. This, in turn can transmute a weak, non-functional tissue, into its healthier equivalent, further permitting it to be less swollen and offering considerable pain reduction as well as functional renovation.

Stem cells therapies have been frequently employed as treatment segment via last couple of decades, in treating countless aberrations related to the blood cancer; in fact, routine application of stem cells therapies have protected life of millions of kids universally, who have been struggling with lethal illnesses, such as childhood leukaemia. Furthermore, their differentiation capacity has as well been endorsed in multiplicity of clinical studies, conducted internationally to treat bone injuries, skin injuries and muscular problems. Thus far, transplantation of antilogous stem cells from multiplicity of body sources, such as bone marrow and/or adipose tissues, etc. are found to be extremely recognized. While numerous problems are still restraining their unlimited applications, like number of stem cells to be suffused, augmenting diverse routes of administration and origin of tissue specific stem cells to upsurge the therapeutic outcome. Numerous studies are ongoing in this regard, with every day bringing us one step nearer to their therapeutic application; there is still a lengthy way to efficiently apply the potential of stem cells in medicinal field.

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