– Critical Limb Ischemia (CLI) is a severe blockage of the arteries, markedly reducing blood flow to the hands, feet and legs, and progressing to the point of severe pain, skin ulcers, gangrene or sores. It requires immediate treatment to re-establish blood flow to the affected area or areas.
The risk factors for critical limb ischemia include:
- Sedentary lifestyle
- Overweight or obesity
- High blood pressure
- Age (Men over 60 and women after menopause)
- High cholesterol
- Family history of vascular disease
Following symptoms indicate that you have critical limb ischemia.
Thickening of the toenails
Absent or diminished pulse in the legs or feet
Toe or foot sores, infections or ulcers that will not heal or heal very slowly
Marked decrease in the temperature of your lower leg or foot compared to the rest of your body
Severe pain or numbness in the legs and feet while not moving known as rest pain
Shiny, smooth, dry skin in the legs or feet
Pain at rest, gangrene and non healing wounds are the manifestation of Critical Limb Ischemia. It is described as a burning pain in the arch or distal foot that occurs while the patient is recumbent but is relieved when the patient returns to a position in which the feet are reliant. Objective hemodynamic parameters that carry the diagnosis of critical limb ischemia include an ankle-brachial index of 0.4 or less, an ankle systolic pressure of 50 mm Hg or less, or a toe systolic pressure of 30 mm Hg or less. Interference may include conservative therapy, revascularization or amputation. Progressive gangrene, rapidly enlarging wounds or continuous ischemic rest pain can indicate a danger to the limb and advise the need for revascularization in patients without prohibitive operative risks. Bypass grafts are usually required because of the multilevel and distal nature of the arterial contraction in critical limb ischemia. Patients with diabetes are more likely than other patients to have distal disease that is less agreeable to bypass grafting. Compared with amputation, revascularization is more affordable and is linked with better pre-operative morbidity and mortality. Limb preservation should be the aim in most patients with critical limb ischemia.
– An objective measurement of blood flow using a hand-held Doppler probe and a blood pressure cuff. The cuff is inflated until the pulse distal to the cuff is no longer heard by Doppler. The cuff is then slowly deflated until the pulse is again detected. This measurement is recorded as the systolic pressure. An ankle systolic pressure of 50 mm Hg or less or a toe systolic pressure of 30 mm Hg or less suggests the presence of critical limb ischemia.
Ankle-brachial index is another widely used parameter in the diagnosis of critical limb ischemia.
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- Qualification for the treatment: Our experts will investigate your past medical history and symptoms to assess the severity of your condition. A series of tests will be performed to understand the stage of disease. As per the test results, our experts will counsel the patient for further process of the procedure.
- Source Extraction: With guidance and approval from the physician, the source of extraction will be decided. In general, WJ-MSCs are the most potent allogenic sources available. Stem cells from a healthy person (the donor) are transferred to the patient’s body. A bone marrow donor is considered for allogenic stem cell transplantation. A scraping from the inside of the patient and his or her sibling’s cheek is tested to determine tissue type. An expert will examine to identity Human Leukocyte Antigens (HLAs). If the HLA on the donor cells are identical or similar, the transplant is more likely to be successful.
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1.What Is essential Limb Ischemia?
It is the foremost severe and progressive from of blood vessel occusion disorder. Patients with CLI can have severe leg pain at rest primarily attributable to poor blood flow. If unattended for an extended amount of your time, it will type severe gangrene resulting in limb loss.
2.What square measure the chance factors related to the malady ?
Critical Limb anemia is that the finish stage disorder of coronary artery disease. the foremost usually listed risk factors related to the disorder is age, smoking, overweight, diabetes, high force per unit area, high sterol etc.
3.What square measure the signs and symptoms of the disease?
CLI is a lot of wish to be found in patients with the history of high force per unit area, high sterol or blood vessel blockages. Out of the numerous outstanding options the foremost obvious square measure pain or symptom within the feet, shiny, dry skin of the foot, Thickening of the toenails, Opened sores or ulcers, Dry black skin of the legs.
4.How is it conventionally treated?
Conventionally surgical operation, Stents or bypassing the artery through surgery square measure prescribed relying upon the severity of the malady. but recovery or reversal of injury isn’t warranted, in addition these approaches square measure related to several aspect effects.
5.What is the ultimate outcome of its progression ?
Since it’s a progressive disorder, if ulcers left untreated for an extended amount of your time they’ll cause limb loss.
6.How will stem cells be useful to treat?
Undifferentiated adult autologous stem cells square measure mutable and may metamorph into enumerable range of cells as per the necessity. This exceptional property of stem cells is exploited for treating style of diseases. These cells is isolated from the foremost potent sources of our own body called animal tissue and Bone Marrow. Upon implanting into the body, these cells will speedily multiply with the good speed to revive broken fibres, revasculatur to bypass the blocked artery likewise will improve broken perform.
7.Why is stem cells treatment higher than typical treatment approach?
Conventional treatment approach extremely invasive related to several aspect effects. though stem cells will naturally heal the body from injury and regenerate lost neurons to enhance impaired functions. in addition since body’s own cells square measure used for repairing, the whole treatment is minimally invasive with none aspect effects.
The scrutiny of protocol for vascular surgery by the University of Crete in Greece was recently published as “Autologous Mesenchymal cells for the treatment of patients with critical limb ischemia”. The outcomes exhibit the likelihood of a promising treatment.Seven patients underwent the treatment; all of them having been recommended to undergo a limb amputation operation.
The average age of the patient group was 69 years. Three had already undergone prior amputation prior to treatment. Four patients were diabetic and three suffered from hypertension. Two patients had hyperlipidemia and/or suffered from stenosis of superficial femoral artery.3 patients out of the total 6 improved post-treatment thus not necessitating amputation. One of the two unlucky patients underwent amputation while the other patient has declined to give approval for the process even when it has become a tremendously necessary medical decision. Ankle-brachial pressure index (ABPI) which measures the blood pressure of the lower zone of legs in comparison to that of the arms, specified that before the stem cell treatment, all the patients had severe arterial impairment. Post-treatment the index amended by about 29% advising that the patients’ condition improved post treatment and they are of the moderate arterial damage grouping.
The treatment permitted patients to walk better and the grievances of pain in the affected limb reduced by practically 22%. It is must be cited that the two patients who did not profit from the treatment belonged to the subcategory suffering from stenosis of superficial femoral artery.
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