Ankylosing Spondylitis is a type of arthritis that affects the spine. A rigid spine is the resultant of the spine’s bone growing or fusing together. The changes may be mild at first or severe leading to a stooped-over posture. Diagnosis and treatment of the disease at the initial stage may help control pain and stiffness, and also prevent significant deformity.
It can occur at any age, however, strikes men in their teens and 20s. It is less common and generally milder in women. About 0.1% to 0.5% of the adult population is affected by Ankylosing Spondylitis. With advancements in the field of medicine, doctors now have a cure which is Ankylosing Spondylitis stem cell therapy.
This inflammatory disease can cause some of the vertebrae in your spine to fuse together. This fusion makes the spine less flexible and can result in a hunched-forward posture. If ribs are affected, it may be difficult to breathe deeply. Stem cell treatment for Ankylosing Spondylitis can pose as a cure to the trouble.
Ankylosing spondylitis affects men more often than women. Signs and symptoms of Ankylosing spondylitis typically begin in early adulthood. Inflammation can also occur in other parts of your body — most commonly, your eyes.
There is no cure for Ankylosing spondylitis, but treatments can reduce your pain and diminish your symptoms, one such treatment is Stem cell treatment for Ankylosing Spondylitis in India.
You must visit your doctor if you are suffering from lower back or buttocks pain that increased gradually little by little, and is now worse in the morning or awakens you from your sleep in the second half of the night — particularly if this pain perks up with exercise and worsens with rest. You must see an eye specialist (ophthalmologist) right away if you develop a painful red eye, severe light sensitivity or blurred vision.
The most common symptoms of Ankylosing Spondylitis are:
- Pain and stiffness
- Pain in ligaments and tendons
- Loss of appetite
- Eye inflammation
It is important to note that the route of ankylosing spondylitis differs greatly from individual to individual, so too can the beginnings of symptoms. Although, symptoms usually begin to appear in late adulthood or early adulthood (ages 17-45), the symptoms can occur in children or much later.
Usually, the first symptoms of AS are frequent pain and stiffness in the lower back and buttocks which develops over the course of time. Initially, discomfort may only be felt on one side, or alternate sides. The pain is usually dull and scattered, rather than restricted. This pain and stiffness is usually worse in the mornings and during the night, but may be better by a warm shower or light exercise. Also, in the early stages of AS, there may be mild fever, loss of appetite and general discomfort. It is important to note that back pain from ankylosing spondylitis is inflammatory in nature and not mechanical.
The pain does not start in the lower back, but in a peripheral joint such as the hip, ankle, elbow, knee, heel or shoulder in few AS affected population. This pain is commonly caused by enteritis, which is the inflammation of the site where a ligament or tendon attaches to bone. Inflammation and pain in peripheral joints is more ordinary in juveniles with AS. This can be confusing since, without the pressing presence of back pain, AS may look like some other form of arthritis.
The diagnosis of Ankylosing spondylitis is based on several factors, including:
- Measurements of the chest when breathing
- X-rays of the back and pelvis
- Findings of a physical exam
- Results of lab tests
Latest researches have revealed that MSCs can help repair and renew nerve cells, improving symptoms and prolonging lives. Steroids and other disease modifying drugs cannot cover all the symptoms and are aimed to manage only specific symptoms. Again, the concern of critical side effects of drugs is also there. With MSC treatment, there is no such concern.
In StemCellCareIndia, we use the unique technology of Mesenchymal stem cells extracted from Wharton’s jelly (WJ) for treating MS. WJ-MSCs offer cost-effective and pain-free collection method that may be cryogenically stored, and are extremely favourable for tissue engineering purpose. They might help in the three prominent ways – prevent damage, repair damage and develop new medicines. The treatment will take place in multiple steps comprising of:
- Qualification for the treatment: Our experts will investigate your past medical history and symptoms to assess the severity of your condition. A series of tests will be performed to understand the stage of disease. As per the test results, our experts will counsel the patient for further process of the procedure.
- Source Extraction: With guidance and approval from the physician, the source of extraction will be decided. In general, WJ-MSCs are the most potent allogenic sources available. Stem cells from a healthy person (the donor) are transferred to the patient’s body. A bone marrow donor is considered for allogenic stem cell transplantation. A scraping from the inside of the patient and his or her sibling’s cheek is tested to determine tissue type. An expert will examine to identity Human Leukocyte Antigens (HLAs). If the HLA on the donor cells are identical or similar, the transplant is more likely to be successful.
- Laboratory Processing: The extracted samples will be sent to government approved cGMP laboratory for processing. The sample manipulation will take place in a state-of- art facility in compliance with the ISO and GMP standards and using the latest technologies. The client will receive a third party certificate from internationally accredited lab for quality purpose.
- Stem Cell Implantation: Once the stem cells are ready to be implanted, the doctor will identify the most potent method of infusion based on the patient’s physical and mental well-being.
Stem cell treatment for Ankylosing spondylitis Aftercare: The patients will be asked to visit the doctors for reclamation therapies such as physiotherapy, counselling, etc. for speedy recovery.
- What is Inflammatory Spondylopathy?
Spondylopathy is a bunch of disorder, involving several chronic joint problems. Although, disorders returning below this cluster have different pathophysiology, the generalized symptoms of all of them are identical. On a general note, symptoms related to the disorder, embrace stiffness within the joints and thereby restricting movements alongside the changes related to the postures.
- What are the assessments associated with AS?
The assessments of AS are facilitated through the assistance of series of questionnaires that may help your doctor figure out the most effective treatment. From being able to provide you guidance to better manage your issue, you will also be assessed as mentioned below:
The Bath Marie-Strumpell disease score measures the most symptoms of in and of itself as fatigue, back pain, morning stiffness. The score is recorded out of ten basis, a lot of the score is, worse are the symptoms.
The spinal pain can even measure with regard to tub Marie-Strumpell disease score and will be recorded on an individual basis.
The Bath Ankylosing practical Index is scored as per what quantity and level of the disorder affects your ability to hold out day to day tasks.
The work productivity and activity impairment score measures your ability to figure throughout the last week, be it in an exceedingly job or home.
Additionally, different clinical assessments are done like spinal X rays, Specific blood tests like hemoglobin, ESR and serum globulin. Specific genetic tests may be done together with HLA-B27, RA, etc. The patient may be prescribed another imaging confirmations like imaging, X Ray, CT Scan, etc.
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Rahul’s symptoms started with sudden onset of the back pain, which went on to be severe with the whole body aches, upto the extent that he could hardly walk or if he could, he started walking like an old man. Although the initial X ray analysis showed nothing, may be because practically it take several years to show changes associated with the spine. Consequently Rahul had to visit rheumatologists, who confirmed after almost 3 years that he is suffering from AS. His treatment regimen involved diet plan, some oral medications and restricted sports activities.