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Stem Cell Treatment for Ankylosing Spondylitis

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Ankylosing Spondylitis is a type of arthritis that affects the spine. A rigid spine is the resultant of the spine’s bones growing or fusing together. The changes may be mild or severe leading to a stooped-over posture. Diagnosis and treatment of the disease at the initial stage may help control pain and stiffness, and also prevent significant deformity.

It can occur at any age, however, strikes men in their teens and 20s. It is less common and generally milder in women. About 0.1% to 0.5% of the adult population is affected by Ankylosing Spondylitis.


This inflammatory disease can cause some of the vertebrae in your spine to fuse together. This fusion makes the spine less flexible and can result in a hunched-forward posture. If ribs are affected, it may be difficult to breathe deeply.

Ankylosing spondylitis affects men more often than women. Signs and symptoms of ankylosing spondylitis typically begin in early adulthood. Inflammation also can occur in other parts of your body — most commonly, your eyes.

There is no cure for ankylosing spondylitis, but treatments can reduce your pain and diminish your symptoms.

You must visit your doctor is you are suffering from lower back or buttock pain that came on little by little, is worse in the morning or awakens you from your sleep in the second half of the night — particularly if this pain perk up with exercise and worsens with rest. You must see an eye specialist (ophthalmologist) right away if you develop a painful red eye, severe light sensitivity or blurred vision.

The most common symptoms of Ankylosing Spondylitis are:

Pain and stiffness

Pain in ligaments and tendons

Loss of appetite

Eye inflammation


It is important to note that the route of ankylosing spondylitis differs greatly from individual to individual, so too can the beginnings of symptoms. Although, symptoms usually begin to appear in late adulthood or early adulthood (ages 17-45), the symptoms can occur in children or much later.

Usually, the first symptoms of AS are frequent pain and stiffness in the lower back and buttocks which develops over the course of time. Initially, discomfort may only be felt on one side, or alternate sides. The pain is usually dull and scattered, rather than restricted. This pain and stiffness is usually worse in the mornings and during the night, but may be better by a warm shower or light exercise. Also, in the early stages of AS, there may be mild fever, loss of appetite and general discomfort. It is important to note that back pain from ankylosing spondylitis is inflammatory in nature and not mechanical.

The pain does not start in the lower back, but in a peripheral joint such as the hip, ankle, elbow, knee, heel or shoulder in few AS affected population. This pain is commonly caused by enteritis, which is the inflammation of the site where a ligament or tendon attaches to bone. Inflammation and pain in peripheral joints is more ordinary in juveniles with AS. This can be confusing since, without the pressing presence of back pain, AS may look like some other form of arthritis.

The diagnosis of Ankylosing spondylitis is based on several factors, including:

  • Symptoms
  • Measurements of the chest when breathing
  • X-rays of the back and pelvis
  • Findings of a physical exam
  • Results of lab tests

Latest researches have revealed that MSCs can help repair and renew nerve cells, improving symptoms and prolonging lives. Steroids and other disease modifying drugs cannot cover all the symptoms and are aimed to manage only specific symptoms. Again, the concern of critical side effects of drugs is also there. With MSC treatment, there is no such concern.

In StemCellCareIndia, we use the unique technology of Mesenchymal stem cells extracted from Wharton’s jelly (WJ) for treating MS. WJ-MSCs offer cost-effective and pain-free collection method that may be cryogenically stored, and are extremely favourable for tissue engineering purpose. They might help in the three prominent ways – prevent damage, repair damage and develop new medicines. The treatment will take place in multiple steps comprising of:

  • Qualification for the treatment: Our experts will investigate your past medical history and symptoms to assess the severity of your condition. A series of tests will be performed to understand the stage of disease. As per the test results, our experts will counsel the patient for further process of the procedure.
  • Source Extraction: With guidance and approval from the physician, the source of extraction will be decided. In general, WJ-MSCs are the most potent allogenic sources available. Stem cells from a healthy person (the donor) are transferred to the patient’s body. A bone marrow donor is considered for allogenic stem cell transplantation. A scraping from the inside of the patient and his or her sibling’s cheek is tested to determine tissue type. An expert will examine to identity Human Leukocyte Antigens (HLAs). If the HLA on the donor cells are identical or similar, the transplant is more likely to be successful.
  • Laboratory Processing: The extracted samples will be sent to government approved cGMP laboratory for processing. The sample manipulation will take place in a state-of- art facility in compliance with the ISO and GMP standards and using the latest technologies. The client will receive a third party certificate from internationally accredited lab for quality purpose.
  • Stem Cell Implantation: Once the stem cells are ready to be implanted, the doctor will identify the most potent method of infusion based on the patient’s physical and mental well being.

Treatment Aftercare: The patients will be asked to visit the doctors for reclamation therapies such as physiotherapy, counselling, etc for speedy recovery.

1.What is Inflammatory Spondylopathy?

Spondylopathy is a bunch of disorder, involving several chronic joint problems. Although, disorders returning below this cluster have different pathophysiology; the  generalized symptoms of all of them ar identical. On a general note, symptoms related to the disorder embrace stiffness within the joints and thereby  restricted movements alongside the changes related to the postures.


2.What are the assessments associated with AS?

The assessments  of the AS are through with facilitate the assistance of series of questionnaires that may help  your doctor to figure out the most effective thanks to manage along with your issue. you will be  assessed as mentioned below:

The Bath Marie-Strumpell disease  score measures the most symptoms of in and of itself as fatigue, back pain, morning  stiffness. The score is recorded out of ten basis, a lot of the score is, worst are  the symptoms.


The spinal pain can even  measure with regard to tub Marie-Strumpell disease score and will be  recorded on an individual basis.


The Bath Ankylosing practical  Index is scored per what quantity your disorder affects your ability to hold out day to day tasks.


The work productivity and  activity impairement score measures your ability to figure throughout the last week,  be it in an exceedingly job or home.


Additionally, different clinical assessments are done like spinal X rays, Specific blood tests  like hemoglobin, ESR and serum globulin.  Specific genetic  tests may be done together with HLA-B27, RA, etc. The patient may be  prescribed another imaging confirmations like imaging, X Ray, CT Scan,  etc.



3.What are the everyday AS symptoms?

General AS  symptoms embrace painful stiffness of the lower back, hips, etc. worsening commonly within the morning. Over the amount of your time, the pain and stiffness could  progresses towards the spine and different joints. The person with AS, could show round-backed posture, inability to figure severally and reduced quality.  Gradually, he may notice issue in bending the spine. options like  loss of craving, fatigue, weight loss, inflammation of the attention and/or different  muscular organs of the body, may be determined.


4.I think I even have AN AS, wherever am i able to get help?

If you  experiencing any of the higher than mentioned, AS symptoms, you ought to straightaway  visit AN medical science doc. to understand a lot of regarding the complication associated  with the disorders, doable treatment choices and the way novel stem cells  treatment will assist you to manage along with your progressive disorders, you’ll visit our web site.


 5.What really happens in AS?

If you’re  suffering from chronic AS, your spinal vertebrae ar utterly consolidated not permitting movement flexibility to your backbone. This leads to the severe  inflammation of the joints, amendment within the body posture, enlargement within the chest  skeleton and progressive stiffness of all the joints of your body. within the later  progression, the wellness could have an effect on you respiratory capability, freedom as  well as different very important muscular organs of the body like eye, heart, kidney,  etc. The disorder is commonly referred to as because the “baboo spine” as a result of your spine tends to induce stiff sort of a bamboo.


6.What are the factors answerable for AS?


Although, the actual causes don’t seem to be noted, the folks expressing HLA-B27 genes are noted to be a lot of prone for identical. within the background, numerous factors ar determined to be answerable for the sequence activation like pathology, general infection, metabolic  disorders, etc.


7.Can AS cause any incapacity in me?


Mild, moderate  or severe disabilities are knowledgeable by several of the folks with AS, relying upon the progression of the unwellness and immunity level. As each  person portrays completely different manifestations, the severity of the unwellness varies  from person to person. If well managed within the initial stages, it’s terribly doubtless  that the progression is stopped.


8.What are the standard treatments for my AS? Are they Helpful?

As such with the facilitate of ancient drugs, no complete cure is out there for your AS, but doctors will counsel some endocrine medications to stay you going. Although, long run use of steroids is harmful to overall health of the body, inflicting numerous unsafe facet effects. relying upon the severity of the unwellness,  doctors will similarly counsel joint replacement surgeries that ar so terribly painful,  attracting several expedient infections.


9.Is there any different to ancient medicines? What are the  benefits?

Yes, Stem cells  treatment is that the distinctive different approach bestowed to you by the fashionable drugs, to assist you reverse back your harm related to the unwellness with none harmful facet effects or surgeries.


10.What are stem cells and the way they will be helpful?

Stem cells ar  the distinctive, pristine cells; isolated from the richest sources of your own body like Bone Marrow and/or fat. These cells are proven to be having a possible to change into many alternative cells of kind of different lineages in  your body upon correct signaling. So far, these cells are exploited with success to differentiate into animal tissue, osteogenic, chondrogenic, blood  lineages. These cells is isolated outside the body, enriched in an exceedingly clean atmosphere and established  back at the location of injury to market regeneration of  lost cells, repairing broken ones, and enhance the practical capability  of the organ.

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