Stem Cell Treatment for Adrenoleukodystrophy

There are several symptoms of Adrenoleukodystrophy that a patient can experience and can be aware of the disease. Here are some of them:

• Behavioral Changes: Kids often have times when they feel very energetic and sometimes get angry or have quick changes in how they feel.

• Learning Problems: It might be hard to remember things, stay focused, and in academics.

• Vision and Hearing Loss: Gradual deterioration in vision and hearing can occur.

• Muscle Weakness: Weakness and stiffness in the legs may develop, affecting mobility.

• Coordination Issues: Balance and coordination problems may manifest, leading to frequent falls.

• Speech Difficulties: Slurred speech or difficulty articulating words may occur.

• Seizures: Epileptic seizures may occur in some cases.

• Swallowing Difficulties: Trouble swallowing or choking while eating can be observed.

• Skin Changes: Changes in skin pigmentation or texture may occur, such as darkening or thickening.

• Hormonal Imbalances: When your adrenal glands aren’t working right, it messes with your hormones. This can make you feel tired, lose weight, or feel thirsty and pee a lot.

These signs can change a lot and can start at different times depending on the type of ALD and the person who has it. Finding out about a disease early and getting help quickly are really important. It helps manage the illness better and makes things better in the end.

Adrenoleukodystrophy (ALD) is a rare disease and can affect the nervous system and adrenal glands of the human body. It primarily affects males, although females can carry the gene.This disease can be caused due to the several mutations in the ABCD1 genes. These genes are found on the X-chromosome. Adrenoleukodystrophy has many types and these types are based on the age of onset and severity of its symptoms:

1. Childhood Cerebral ALD (CCALD):

• This type of Adrenoleukodystrophy can occur in boys usually between the ages of 4 and 10.
• Its symptoms include behavioral problems, learning difficulties, and loss of vision and hearing.
• Progression can be rapid, leading to severe disability or death within a few years.

2. Adrenomyeloneuropathy (AMN):

• The most common type of ALD is adrenomyeloneuropathy and can affect the males usually in their 20s or 30s.
• Weakness in the legs, stiffness, and difficulty walking are the symptoms of this type.
• Progression tends to be slower than CCALD, with some individuals remaining stable for many years.

3. Adrenal Insufficiency (Addison’s Disease):

• It can occur in any type of ALD.
• When the adrenal glands are hurt, it can mess up the hormones in your body.
• Fatigue, weight loss, and low blood pressure are the symptoms you may experience..

4. Adrenal ALD:

It is presented mainly in infants.

It involves adrenal gland dysfunction without neurological symptoms.

It can lead to adrenal crisis if left untreated, which is life-threatening.

5. Adult-Onset Cerebral ALD:

• This type is the rare form of ALD that presents in adulthood.
• Its symptoms resemble those of CCALD but tend to progress more slowly.

6. Asymptomatic Carrier Status:

• Some females who carry the ALD gene may not develop symptoms.
• However, they can pass the gene on to their children.

Adrenoleukodystrophy diseases vary in their onset, symptoms, and progression, but they all stem from the same underlying genetic mutation. Early detection and management are crucial for improving outcomes and quality of life for affected individuals.

Adrenoleukodystrophy can be caused when ABCD1 genes mutate within the body. The work of these genes is to make proteins which can be useful to break down fats in the body. These fats buildup at the higher level if the body can’t break it properly and the mutation of ABCD1 genes can cause this problem.

ALD can pass from generation to generation because it is a genetic disorder. The mutation of the disease can happen in the X chromosome which is known as the sex chromosome. Since males have only one X chromosome, ALD affects them more than females. Females have two X chromosomes, so even if one copy of the gene is affected, they still have another backup copy.

These fats mostly gather in the adrenal glands, which make hormones for controlling metabolism, and in the myelin sheath, which protects nerve cells. When the covering of nerves, called the myelin sheath, gets hurt, messages from the nerves don’t work right. This can cause problems with walking, talking, and thinking.

ALD is mostly caused by genes, but some things in the environment might also have a part in making it happen. But we need to study more to know exactly how these things work. Testing babies when they are born and checking their genes can help find problems early and make things better.

Early diagnosis of Adrenoleukodystrophy can be helpful to find the major cause of the disease. However, diagnosis in done by some steps which are:

Firstly, doctors look after the symptoms such as problems in vision, difficulty in walking, or behavioral change. If they find out that you have ALD, then they do blood tests to check if there is a high level of fatty acid stored in the body. When the body is unable to break down the fat properly then fatty acid starts to build up.

Next, if the ALD report is positive after the blood tests, the doctors will do genetic tests. This means getting a little bit of blood or saliva to check for changes in certain genes related to ALD. If we find these changes, it can confirm that someone has ALD.

Several other tests like imaging tests which include MRI scans can be used by doctors to check the changes in the brain’s white matter, a sign of ALD. It is necessary to diagnose the symptoms of ALD at its early stage to make treatment more effective. In short, diagnosis can contain the combination of blood tests, genetic tests, and imaging tests

There are several therapies and treatments all over the world that can be used to treat Adrenoleukodystrophy. But, at Stem Cell Care India, our professional team of doctors and researchers use the regenerative power of stem cells to treat this rare disease. Stem cells can be differentiated into different types of specialized cells to treat the symptoms of this medical condition from the roots and provide patients the quality of life they want.

In stem cell therapy, healthy stem cells which are taken by allogeneic or by autologous method will be transplanted to the patient’s body. After that these cells divide themselves into different types of cells which are needed to repair the damaged cells and tissues. If a patient of ALD comes to our clinic hospital, then our main focus is to replace the damaged cells with the healthy and new ones which will be beneficial to produce the protein needed to cut down the fatty acid.

One common method is a bone marrow transplant. In this procedure, healthy stem cells from a donor’s bone marrow are injected into the patient. This can help rebuild the patient’s immune system and give the needed cells to stop ALD from getting worse. While this treatment gives hope, it is still being tested and has risks, like the chance that the body might reject the new cells.

Usually, it is the three day procedure of Adrenoleukodystrophy stem cell therapy at Stem Cell Care India. Procedure is briefly explain below:

Day 1:

• Pick you up from the airport.
• Doctor and patient talk to each other to clear up all their questions.
• Procedure of admission.
• Doctor prescribed some clinical examinations & lab tests to be done on the same day.
• Supportive therapy.

Day 2:

• Procedure of stem cell.
• Supportive therapies provided.
• And also physiotherapies.

Day 3: 

• Some supportive therapies and physiotherapies.
• Procedure of discharge will be done.
• Drop off at the airport.

Note to remember: Patients have to carry their ID proof (PAN card, Adhaar card, Driving license) with themselves for the admission process. You should also carry your hard copy of the medical history report.

Adrenoleukodystrophy (ALD) is a rare disease that can be caused due to mutation of ABCD1 genes which can be found in the X-chromosomes. This gene is helpful to break the fatty acid in the body. If a patient is suffering from this medical condition, then we will consider taking stem cell therapy to treat it. Our professional doctors take out the autologous mesenchymal stem cells from patients’ own bone marrow. Then, isolate the stem cells form the bone marrow with the help of the special machine. These stem cells are injected directly into the spinal fluid through a procedure known as intrathecal infusion.

After that, The remaining bone marrow is sent to a laboratory where the cells are amplified. This method aims to create a custom treatment plan for each patient, increasing the chances of success. This implantation shown successful by following ways:

• Intravenous administration
• Liberation angioplasty
• Intrathecal (lumber puncture)
• Intraarterial
• Subcutaneous
• Surgical administration for stroke
• Intramuscular

When we use cells from the patient’s own body, there’s less chance of rejection, and it helps the body heal naturally. Putting stem cells into the body could help people with ALD feel better and make the disease go faster than other treatments.

Q1. What is Adrenoleukodystrophy (ALD)? 

Ans: ALD is a rare sickness that messes up the nerves and glands in your body. It happens because of a change in a gene that affects how the body breaks down certain kinds of fats. This change in genes causes fat to build up in the body, harming the protective layer around nerve cells in the brain and spine. Symptoms can be different for each person but might include having trouble thinking, walking, having seizures, or problems with the adrenal glands.

ALD mostly affects boys, often showing up when they are kids or teenagers. It’s really important to find it early, which can be done through tests on newborn babies and checking their genes. This helps in taking care of the disease and giving the right treatment.

Q2. What are the types of Adrenoleukodystrophy? 

Ans: Adrenoleukodystrophy is a genetic disorder which is rare and affects most boys in their childhood. This medical condition has different types which are follow:

1. Childhood Cerebral ALD: This type of adrenoleukodystrophy mainly affects boys in their childhood and gets worse if not treated properly. Patients can experience losing their skills and become paralyzed.

2. Adrenomyeloneuropathy (AMN): This type can happen to both men and women. The signs usually begin when you’re grown up and get worse slowly. It makes your muscles weak and makes it hard to walk.

3. Addison’s Disease: In addison’s disease, patients’ adrenal glands don’t work well. Adrenal hormones control how our bodies use energy and handle stress. If these hormones are too high or too low, it can be really dangerous. Doctors can figure out the problem and give supplements to help balance the hormones and keep us healthy.

4. Female ALD: Women who get the bad gene for ALD might not get the brain sickness, but they could have small signs. These signs usually begin after they turn 35. Patients will experience various symptoms such as weakness, numbness, joint pain, and urinary problems.

Q3. Is there a treatment for ALD? 

Ans: ALD has no cure yet but its symptoms can be treated by using stem cell therapy in India. Doctors harness the regenerative potential of stem cells to restore the damaged tissues. These cells have the ability to differentiate themselves into different cell types and treat the root cause of the disease.

However, the effectiveness of stem cell therapy depends upon various factors such as what type of stem cells you took, age of the patient, severity of the disease, and more. Other basic things can also help stem cell therapy to speed up the recovery rate which include the right diet, medication, and some helpful therapies recommended by doctors. It is really important to talk to doctors who know a lot about medicine before deciding if stem cell treatment is right for someone. They can help figure out if it’s good for the person’s particular problem and if the good things about it are worth any possible bad things.

Q4. Can adrenoleukodystrophy be considered an autoimmune disorder? 

Ans: Many people think that ALD is an autoimmune disorder but it is not. It is a rare type of genetic disorder which can be passed to the generations. It is caused when the body is unable to break certain fats properly. This causes a build-up of fatty acids that harm the protective layer of the nervous system, called myelin. Autoimmune disorders occur when the immune system makes a mistake and attacks the body’s own tissues.

ALD isn’t caused by the body’s immune system reacting. Instead, it happens because of changes in certain genes. These changes mess up how the body handles fats. Autoimmune disorders, such as lupus or rheumatoid arthritis, happen when the immune system mistakenly attacks healthy tissues. But ALD comes from genetic issues that mess with how the body deals with fats.

Q5. Why should I choose stem cell therapy for ALD? 

Ans: There are several types of treatment options available in the medical field which can treat the symptoms of adrenoleukodystrophy. But, one of the best and effective ways to treat ALD is stem cell therapy because it has the differentiate capability to restore the damaged cells with the new one. On the other hand, this therapy has many benefits such as reducing the risk of complications, enhancing cognitive and motor function, reducing inflammation, and many more.

This therapy is more effective and affordable than conventional treatment. Also, people are hoping for innovative medical options because of their properties. Stem cell therapy is now becoming the future of regenerative medicines. This treatment might help slow down or even stop the progress of ALD, making life better for patients. Stem cell therapy is a hopeful option for fighting ALD. It is safer than surgeries or drugs that can have bad side effects.

Adrenoleukodystrophy is hard to treat by any ancient treatment. Therefore, Stem Cell Care India introduces stem cell therapy to treat this medical condition from its root cause. After taking this therapy, patients experience better muscle control which helps them in walking and coordination. They notice enhancement in communication and other cognitive functions such as thinking, memorization, etc. There are some other improvements can be shown if you take this innovative treatment which are:

• Enhancement in hearing and vision.
• Better quality of life.
• Less progression of neurological damage.
• Reduction in seizures.

There are several ways to treat adrenoleukodystrophy but stem cell transplantation is becoming the hope of many individuals. Medical institutes use diverse kinds of stem cell technologies to make the treatment successful. But, if you are talking about promising stem cells, then it would be mesenchymal stem cell transplantation. This transplantation is famous and has many benefits to treat various medical conditions including adrenoleukodystrophy. Let’s take a look on its mechanism on ALD:

• MSCs can reduce the inflammation in the brain because it can release the substance which helps to stop the inflammation that damages the myelin. It slows down the damage process because of its anti-inflammatory properties.

• MSCs can release growth factors and other molecules that help repair and regrow myelin. This can help rebuild the protective covering around nerve cells.

• The immune system affects how ALD (Adrenoleukodystrophy) progresses. MSCs (Mesenchymal Stem Cells) can change how the immune system works, making it less harmful. This might help prevent more damage to myelin, the protective covering of nerves.

• MSCs can move to injured or inflamed areas. When put into the body, they can travel to the brain where they are needed the most.

MSC transplantation shows promise, but it is still being studied. Scientists are doing clinical trials to find out how safe and effective this treatment is for ALD. If it works, MSC transplantation could offer a new method to control or even slow down this terrible disease.

People are finding the best quality treatment which helps them to treat adrenoleukodystrophy that’s why Stem Cell Care India is becoming the preferable stem cell centre in India. Our approach is to provide top-notch stem cell therapy to reduce the symptoms of ALD and get back their quality of life. We use only high-quality mesenchymal stem cells derived from the patient’s own body, cultivate it by the use of modern technologies and inject it to the affected area. This method needs expertise and effectiveness and we promise both. Our commitment is to provide you the best treatment which helps your body to release natural protein to break down the certain fats. You can get personalized treatment options as per patient requirement to fulfill all your needs. At our clinic, our professional will take care of you with good hospitality and further other things that you need.

Various medical institutions provide stem cell treatment for adrenoleukodystrophy but the margin of price seems to be high. Stem Cell Care India notes down the basic and higher requirements of the patients and then provides them the best quality stem cell treatment which is affordable than many western countries. You will get the finest mesenchymal stem cell transplantation at affordable prices if you take it from us. Now, you are thinking if the prices are this low, then treatment will also be cheaper. No, we provide fresh stem cells so that your treatment gets success. There are some factors that can fluctuate the price and that are, types of stem you want, severity of the condition, treatment personalization, etc.

The important factor of a treatment is its success rate. If a treatment shows a high number of possible outcomes, then people will only take that treatment to treat their medical condition. Stem cell for ALD in India shows the successive results because it has the potential to fight the main cause of the disease and reduce the progression of it. Stem cell therapy utilizes the power of stem cells to reduce the symptoms and inflammation. Stem cells have anti-inflammatory and regenerative properties that help them to replace the damaged tissue with the new ones. However, the success depends on early diagnosis and the patient’s condition.

Stem cell therapy for ALD in India provides several advantages to the person who is suffering from this rare type of genetic disorder. Here are some of the benefits you will get if you take the treatment:

• Halting Disease Progression: Stem cell therapy can help ALD by putting healthy cells in the brain and spinal cord where damaged ones are, so the sickness doesn’t get worse or might even stop.

• Early Intervention: Giving stem cell treatment early in the disease can work better because it stops serious symptoms from happening.

• Reduce the Risk of Rejection: Because stem cells can come from a person’s bone marrow or umbilical cord blood, there is less chance their body will reject them, unlike with organ transplants.

• Reducing Reliance on Medication: Treating the problem well might mean you don’t need as much medicine to handle the symptoms. This could mean fewer side effects and less money spent on healthcare.

• Minimal Side Effects: Stem cell therapy causes fewer problems than regular treatments because it uses your own cells to help you get better.

• Affordability: Stem cell therapy is cheaper than other treatment options which make them the most preferable and ideal choice.

Stem Cell Care India ensures that their stem cell therapy for adrenoleukodystrophy (ALD) is safe and effective through strict quality control measures. Here is how we maintain high standards:

• Rigorous Screening: We carefully check donors to make sure they are very healthy to reduce the risk of spreading diseases through stem cells.

• Accredited Facilities: Our labs and facilities are approved by official organizations that make sure we follow quality standards at every step of the treatment process.

• Comprehensive Testing: Stem cells undergo thorough testing for purity, potency, and safety before being used in therapy which reduces the likelihood of adverse reactions.

• Expert Oversight: Our team of skilled doctors and scientists manage all procedures of the treatment to ensure it is accurate and effective.
• Quality Checks: To make sure stem cell treatments are consistent and reliable, many quality checks are done during processing and preparation stages.

Patients can experience several changes in their conditions after taking ALD stem cell therapy at Stem Cell Care India. Stem cell therapy replaces the damaged cells with the new ones that help the patient body to recover fast and improve neurological functions. There are various positive outcomes patients can notice if they take stem cell therapy from us. Some of them are improvements in their motor skills which include better coordination and muscle strength. Many patients told us that their cognitive functions are improving day by day. This therapy not only helps them to recover from their state, but also provides long term benefits.

Hi my name is Mohd. Imaan and I are thankful to Stem Cell Care India to save my son from this dangerous disorder. My son Akram was diagnosed with adrenoleukodystrophy when he was 6 years old and we were worried about his condition because there is no treatment available that can treat my son. But, eventually, I found Stem Cell Care India which is known for their stem cell therapy for ALD. I got an appointment with them easily and took us from the airport to the hospital. I was scared but they provide us the courage to confront the challenges. Their hospital environment is amazing and so are the doctors too. Their team of professionals diagnosed my son’s health and made a personalized one which is suitable for him. The treatment procedure was transparent and provided us all the necessary details. It’s been 5 months and my son is living his quality of life. Thank you Stem Cell Care India. — Mohd. Imaan, UAE.

Hello,I am Carla Grey and I am from Colombia. My little sister Kelly is a patient of Adrenoleukodystrophy which is a rare type of genetic disorder. I studied about it and found out it is a dangerous medical condition. When our family found that Kelly is suffering from ALD, they were scared because research says there is no guaranteed treatment that can be made to treat this disease. Then, some of my Indian friends suggested to me about Stem Cell Care India,a reputed stem cell centre in India which treats various medical conditions. My family flew to India with my little sister and admitted her to hospital. The procedure is of three days and covers many treatments. Doctors are very friendly and talk with us politely. After the treatment Kelly’s motor skills and cognitive function starts improving. Now, she is totally fine. We are very thankful to Stem Cell Care India. — Carla Grey, Colombia.

My name is Laura Gaby and I am 12 years old. I am here to describe my story of how Stem Cell Care India helped me to get over from the dangerous genetic disorder called Adrenoleukodystrophy. I was 10 years old when I was diagnosed with ALD. My family got tense when they found out about my condition. Slowly my cognitive function starts diminishing and my thinking skills are reduced. I lose faith that I will ever get treated. But, then my aunt suggested my parents to take me to India. There is a well known stem cell therapy centre named Stem Cell Care India. My father booked an appointment with them. When we reached the hospital the team of doctors diagnosed me and asked me some questions. They also told me that if there are any questions I want to ask them. They are very helpful and listen to my concerns. On the next day, the treatment procedure starts. After the treatment, they provided me with some supportive therapies and physiotherapies to speed up my recovery. I am feeling some changes in my body now. My cognitive function is improving and I don’t feel any side effects till now. I am glad that I get treatment from them. — Laura Gaby, Israel.

The Quality Certificate for adrenoleukodystrophy stem cell therapy at Stem Cell Care India ensures the highest standards of treatment. It confirms that the therapy is safe, effective, and follows international guidelines. The certificate means the clinic uses advanced technology and skilled professionals for stem cell treatments. Patients can trust that the therapy meets strict quality controls and is regularly reviewed by experts. Stem Cell Care India is dedicated to providing top-notch care, aiming for the best outcomes for patients with adrenoleukodystrophy. This certificate is a mark of their commitment to quality and patient safety.

Follow up is an important step if you are taking stem cell therapy for ALD at Stem Cell Care India. That’s why, we provide this medical care to all our patients to analyze if there are any side effects found in your body after the treatment. Team of experts at our clinic will call you after one, two, or half of a year to see how stem cell therapy is working in your body. This method helps both you and us to make treatment more effective. If we notice any side effects in you, then we immediately provide physiotherapy or other medical treatment to fasten up the speed of recovery. However, regular follow-up improves the chances of success and helps control the disease better

Stem cell therapy for Adrenoleukodystrophy in India seems to be the hope for many individuals who are suffering from this rare genetic disorder. But, like all other treatments, stem cell therapy also may fail to provide the outcomes sometimes because it depends on various factors such as age of the patient, severity of the condition, and many more. Our commitment is to provide the best quality stem cells in our therapy which are safe and effective. We don’t promise that any medical treatment will completely cure you or guarantee how well it will work. However, every patient’s inner body is unique, the outcomes of the disease will be different.