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Stem Cell Treatment for Muscular Dystrophy

A group of inherited diseases in which the voluntary muscles progressively weaken. In some forms of this disease, the heart and other organs are also affected. There are 9 types of muscular dystrophy:

Myotonic

Duchenne

Becker

Limb-girdle

Facioscapulohumeral

Congenital

Oculopharyngeal

Distal

Emery-Dreifuss

In Dystrophy, a particular part of the body weakens or wastes away. In muscular dystrophy, the weakness is in the muscles. An inherited genetic mistake prevents the body from making a protein that helps build muscles and keep them strong. Children who are born with muscular dystrophy usually develop normally for the first few years of life. They may suddenly show signs of clumsiness. These signs include:

trouble walking

difficulty raising the front of their foot (called foot drop)

falling

Over the years, children with muscular dystrophy can become weaker and weaker, walk, losing the ability to sit, and lift objects. The disease can also affect muscles in the heart and lungs, serious heart and breathing problems can also occur. There are different types of muscular dystrophy. Muscle weakness is a trademark of each type. But the symptoms can differ and start at different ages. Some muscular dystrophies are gentle. Others are extreme and cause superior muscle loss. StemCellCareIndia provides effective stem cell muscular dystrophy treatment in Delhi, India.

In muscular dystrophy, the weakness is in the muscles. A genetic abnormality prevents the body from making a protein that helps build muscles and keep them strong. Different forms of muscular dystrophy will have different symptoms, however, some of the common signs are:

  • Difficulty standing
  • Difficulty rising from a lying or sitting position
  • Trouble breathing
  • Trouble learning to sit independently and walk
  • Muscle weakness that begins in the hips, pelvis, and legs
  • Clumsiness, falling often
  • Trouble climbing stairs
  • Unsteady, waddling gait
  • Larger-than-normal calves that is sometimes painful
  • Breathing problems that may eventually require the use of a ventilator
  • Walking on the toes or balls of the feet
  • Learning disabilities or behavioural problems
  • Curvature of the spine (scoliosis) causing one hip to rise higher than the other.

Muscular dystrophy (MD) is diagnosed through a physical exam, a family medical history, and tests. These might include:

  • A muscle biopsy (the removal and exam of a small sample of muscle tissue)
  • DNA (genetic) testing
  • Electromyography or nerve conduction tests (which use electrodes to test muscle and/or nerve function)
  • Blood enzyme tests (to look for the presence of creatine kinase, which reveals deterioration of muscle fibers)

Latest researches have revealed that MSCs can help repair and renew nerve cells, improving symptoms and prolonging lives. Steroids and other disease modifying drugs cannot cover all the symptoms and are aimed to manage only specific symptoms. Again, the concern of critical side effects of drugs is also there. With MSC treatment, there is no such concern.

In StemCellCareIndia, we use the unique technology of Mesenchymal stem cells extracted from Wharton’s jelly (WJ) for treating MS. WJ-MSCs offer cost-effective and pain-free collection method that may be cryogenically stored, and are extremely favourable for tissue engineering purpose. They might help in the three prominent ways – prevent damage, repair damage and develop new medicines. The treatment will take place in multiple steps comprising of

  • Qualification for the treatment: Our experts will investigate your past medical history and symptoms to assess the severity of your condition. A series of tests will be performed to understand the stage of disease. As per the test results, our experts will counsel the patient for further process of the procedure.
  • Source Extraction: With guidance and approval from the physician, the source of extraction will be decided. In general, WJ-MSCs are the most potent allogenic sources available. Stem cells from a healthy person (the donor) are transferred to the patient’s body. A bone marrow donor is considered for allogenic stem cell transplantation. A scraping from the inside of the patient and his or her sibling’s cheek is tested to determine tissue type. An expert will examine to identity Human Leukocyte Antigens (HLAs). If the HLA on the donor cells are identical or similar, the transplant is more likely to be successful.
  • Laboratory Processing: The extracted samples will be sent to government approved cGMP laboratory for processing. The sample manipulation will take place in a state-of- art facility in compliance with the ISO and GMP standards and using the latest technologies. The client will receive a third party certificate from internationally accredited lab for quality purpose.
  • Stem Cell Implantation: Once the stem cells are ready to be implanted, the doctor will identify the most potent method of infusion based on the patient’s physical and mental well being.

Stem Cell Muscular Dystrophy Treatment Aftercare: The patients will be asked to visit the doctors for reclamation therapies such as physiotherapy, counselling, etc for speedy recovery.

1.What is inherited disorder and may stem cells help?

MD’s are a gaggle of disorders characterised by hereditary defects in muscle supermolecule, death of muscular cells and muscular weakness.  Mutations in genes, concerned in muscular membrane structure and performance may welcome the deformity. in theory, if stem cells are injected into the body, they will manufacture traditional muscle cells that are non practical as a result of faulty genes. Some quite stimulation may be useful to multiply residential stem cells and differentiate on their own to muscle cells.

 

2.What are the various stem cells which will supply facilitate for MD?

Stem cells transplantation are of various sorts starting from allogeneic mesenchymal stem cells, funiculus blood derived stem cells, autologous bone marrow and fat derived stem cells, etc. However, out of those, autologous mode of vegetative cell transplantation is thought to be the foremost helpful as body’s own cells ar used they do not impose any threat of rejection of infection.

 

3.How many numbers of stem cells injections are needed to treat MD?

Stem cell injection will begin showing leads to one injection itself, though it’s troublesome to interpret as a result of the therapeutic effectivity of this treatment depends upon the patient’s condition relying upon the uptake of stem cells, severity of the unwellness and age of the patient.

 

4.Does the endocrine drug medical aid used as a traditional means of treating MD is useful?

Rehabilitation in terms of workout is critical, but strenuous means of exercise ought to be avoided. Considering endocrine medical aid, it’s continuously been established to be medically subjective and restricted in usage and thus their future use got to be avoided. the most goal of the steroids is to scale back inflammation throughout inherited disorder. However, their future usage will have an effect on overall good condition of the patient.

 

5.What are the probabilities that a patient can begin walking when stem cells treatment?

Stem cells isolated from autologous tissue sources in conjunction with inhibitor stimulation will improve the muscular strength by make muscle cells. the event has been ascertained in numerous clinical trials. but the results could vary from person to person.

 

6.In my family if my elder brother has doctor’s degree, what are the probabilities of my son obtaining affected with constant and can stem cells injection may be associate degree option?

There are five hundredth probabilities of doctor’s degree deformities in your younger son. However, it’s to be confirmed by molecular nosology and different tests. The stem cells medical aid will work higher in younger patients than older one. the sooner you’ll want the treatment , you’ll recover outcomes.

 

7.How will stem cells be helpful to treat?

Undifferentiated adult autologous stem cells are changeable and may Metamorph into unnumbered numbers of cells as per the necessity. This exceptional property of stem cells may be exploited for treating a range of diseases. These cells may be isolated from the foremost potent sources of our own body referred to as animal tissue and Bone Marrow. Upon implanting into the body, these cells will apace multiply with bigger speed to push regeneration of muscular cells, to help management over your mood swings, to enhance the good condition and overall quality. to boot  a stimulation medical aid may be applied, whereby the organ is aroused to multiply resident stem cells and secrete growth factors to form microenvironment. This treatment can act as a booster to push regeneration.

 

8.Why is vegetative cell treatment higher than standard treatment approach?

Conventional treatment approach extremely invasive related to several facet effects. though stem cells will naturally heal the body from injury and regenerate lost tissue specific cells to enhance impaired functions. to boot, since body’s own cells ar used for repairing, the whole treatment is minimally invasive with none facet effects.

 

9.How do I do know if I’m the correct candidate for the vegetative cell treatment?

There are several necessary problems to be addressed  before choosing the treatment, which might satisfactorily answered solely by specialists. Thus, it’s continuously wise to consult, and want the correct vegetative cell treatment pattern.

 

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