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Stem Cell Treatment for Alzheimer’s disease

Alzheimer’s disease or AD is a severe form of dementia causing a steady memory loss and speech problems and ability to perform daily activities. It gets worse over time, but how quickly this happens varies. The changes in the brain due to the loss of chemical messengers in the brain, called neurotransmitters, that allows nerve cells in the brain to communicate properly are reasons behind the deterioration.

People with AD have two things in the brain that are not normal: amyloid plaques and neurofibrillary tangles. Experts are yet unsure about the presence of these two things as the side effects or part of the cause. The situation of people suffering from AD worsens with time.

Named after the doctor who first described it (Alois Alzheimer), this physical condition affects the brain. There are more than 520,000 people in the United Kingdom alone with Alzheimer’s disease. During the course of the disease, proteins build up in the brain to form structures called ‘plaques’ and ‘tangles’. This leads to the loss of connections between nerve cells, and eventually to the death of nerve cells and loss of brain tissue.

Those with Alzheimer’s also have shortfall of some important chemicals in their brain. These chemicals act as messengers that help to transmit signals around the brain. When there is a shortage of these chemical messengers, the signals are not transmitted as effectively as it should be. Current treatments for Alzheimer’s disease can help boost the levels of chemical messengers in the brain, which can help with some of the symptoms. Stem cell therapies have emerged to be an effective treatment method for Alzheimer.

People with AD may show the following signs.

  • Confused about what time and day it is.
  • Have trouble learning and remembering new information.
  • Have trouble finding the right words to say what you want to say.
  • Get lost in places you know well.
  • Have more trouble doing daily tasks like cooking a meal or paying bills.
  • Have trouble making decisions.

People having these symptoms should visit a doctor right away.

The doctor will do a physical examination to find out the physical problems. A functional status exam followed by mental health assessment will be performed.

Blood tests to be done may include

  • Complete blood count (CBC)
  • Thyroid function tests
  • Vitamin B12 concentration
  • Liver function tests
  • Folate (folic acid) test
  • HIV test, if the person has risk factors for HIV or the medical history suggests it
  • Electrolyte and blood glucose levels (sodium, potassium, creatinine, glucose, calcium)

Other tests may include

  • An electroencephalogram or EEG.
  • A lumbar puncture to test for certain proteins in the spinal fluid.
  • Brain imaging studies, such as positron emission tomography (PET) or single photon emission tomography (SPECT).
  • Brain imaging tests, such as a CT head scan or an MRI of the head.

Latest researches have revealed that MSCs can help repair and renew nerve cells, improving symptoms and prolonging lives. Steroids and other disease modifying drugs cannot cover all the symptoms and are aimed to manage only specific symptoms. Again, the concern of critical side effects of drugs is also there. With MSC treatment, there is no such concern.

In StemCellCareIndia, we use the unique technology of Mesenchymal stem cells extracted from Wharton’s jelly (WJ) for treating MS. WJ-MSCs offer cost-effective and pain-free collection method that may be cryogenically stored, and are extremely favourable for tissue engineering purpose. They might help in the three prominent ways – prevent damage, repair damage and develop new medicines. The treatment will take place in multiple steps comprising of

Qualification for the treatment: Our experts will investigate your past medical history and symptoms to assess the severity of your condition. A series of tests will be performed to understand the stage of disease. As per the test results, our experts will counsel the patient for further process of the procedure.

Source Extraction: With guidance and approval from the physician, the source of extraction will be decided. In general, WJ-MSCs are the most potent autologous sources available. The particular amount of samples will be extracted from the patient’s bone marrow and/or adipose tissue on the intimated date and time. The method of stem cell treatment in Alzheimer does not involve any donors. Patients own stem cells help in the growth of healthy brain tissue. Numerous clinical trials prove that these cells are great for rebuilding damaged nerve fibres. Moreover, because WJ-MSCs are part of the patient’s body, there is no risk of rejection, allergic reactions or side effects.

Laboratory Processing: The extracted samples will be sent to government approved cGMP laboratory for processing. The sample manipulation will take place in a state-of- art facility in compliance with the ISO and GMP standards and using the latest technologies. The client will receive a third party certificate from internationally accredited lab for quality purpose.

Stem Cell Implantation: Once the stem cells are ready to be implanted, the doctor will identify the most potent method of infusion based on the patient’s physical and mental well being.

Treatment Aftercare: The patients will be asked to visit the doctors for reclamation therapies such as physiotherapy, counselling, etc for speedy recovery.

1.What Is alzheimer’s Disease?

Alzheimer’s could be a severe style of insanity, a form of a nervous disorder increasingly damaging memory and thinking skills.  The person will eventually lose its independence even for day to day activities.

 

2.What square measure the signs and symptoms of Alzheimers ?

A person together with his early sickness biological process stage could realize issue in basic cognitive process things; he will raise constant queries once more and once more, have bother managing finances, taking longer than traditional to end daily tasks. An individual may additionally face issue to find the proper words in his speech, impaired reasoning or faultfinding skills. He or she could still expertise mood swings or temperament changes.

 

3.What causes Alzheimer Disease?

Except for a rare style of Alzheimer, known as early onset familial Alzheimers alternative varieties of diseases square measure non genetic. Genetic mutations square measure connected with the kind of associate degree Alzheimer, whereas others square measure directly connected with environmental factors and traumatic scenario long-faced by the body.

 

5.How Alzheimer sickness is diagnosed?

The only thanks to diagnose a sickness are to search out whether or not plaques and tangles square measure gift within the section of the brain. To appear into the tissue, the doctor should perform brain diagnostic check or brain autopsy test, associate degree examination of the brain done once the person dies. Once the person is alive, the identification is totally dependent upon the likelihood or likelihood through examination of general health, past medical issues, case history, asking questions about temperament changes, memory tests, language skills, downside determination capability, and attention.

 

6.How long do folks live once identification?

Although the time from identification to death varied from person to person, it may be as very little as three to five years for the person on top of eighty years mature. For younger patients time could vary between 7-10 years.

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