Systemic lupus erythematosus (SLE) is one of the forms of lupus erythematosus. It is an autoimmune ailment in which the body’s immune system attacks its healthy tissues, generally all tissue systems of the body including the heart, kidneys, joints, lungs and even the blood cells.
Systemic lupus erythematosus generally comes with alternating severe and mild symptoms. Symptoms also differ amongst folks. With treatment, individuals suffering with the ailment can live a normal life. Common symptoms include:
- Joint pain and inflamed joints
- Severe fatigue
- A characteristic rash called butterfly rash that befalls on the nose and cheek
- Hair loss
- Dysfunctional clotting system
- Itchy sensation of the fingers in cold weather; the fingers can also turn white or blue; a condition referred to as Raynaud’s phenomenon.
Some symptoms are specific to the body part being attacked, e.g., heart, skin, excretory and respiratory symptoms.
As per evaluation of the medical history and symptoms, the doctor may suggest blood and imaging test. A liver biopsy may also be advised.
Blood tests to check liver function
- Partial thromboplastin timeor Prothrombin time/INR. These tests measure blood-clotting factors that are produced in the liver.
- Albumin and total serum protein. Albumin is a type of protein. Liver disease can cause a decrease in protein levels in the blood.
- Bilirubin test for checking the level of bilirubin. This is produced when the liver breaks down haemoglobin. High bilirubin causes jaundice.
Blood tests to check inflammation.
There are also tests to check your liver enzymes and liver inflammation.
- Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH). An increased level of these enzymes may mean injury to the liver and the death of liver cells.
- Gamma-glutamyl transpeptidase (GGT). An increased level can happen because of alcohol use or diseases of the bile ducts.
Alkaline phosphatase (ALP). An increased ALP level may mean blockage of bile ducts.
Research conducted lately has given optimistic insights into the possible treatment of systemic lupus erythematosus with mesenchymal stem cells. Mesenchymal stem cells can segregate into bone and cartilage and can help with tissue regeneration. Mesenchymal stem cells are not distinguished by the immune system, making them very useful for treatment of autoimmune ailments such as systemic lupus erythematosus. In the research conducted, mesenchymal cells administered to SLE sufferers were to some degree recruited to zones where swelling is taking place. In this way, they helped with regenerating the impaired tissue. There was a substantial success in the subjects used for the study. However, scientists advised there’s more work to be done in this area. It is also notable that there were no recorded side-effects within the few years they were verified. Scientists are still indeterminate of long-term results of the mesenchymal stem cell treatment.
1.Is a Stem Cell Procedure the same as PRP (Platelet Rich Plasma)?
No. PRP is concentrating platelets in the blood, not stem cell therapy.
2. Do mesenchymal cells stay localized to the injection site? Is there any risk of them traveling throughout the body?
MSC’s do stay localized to the injection place across multiple studies. This is likely related to the fact that they usually do not flow in the blood stream like other adult stem cell types and are chiefly found resident in the tissues they serve.
3. What complications have been confronted with the procedures?
Using the pertinent guidelines for complications reporting, our complications till date have been in the mild to moderate grouping and rare. This means that either the complication (like brief swelling) required no medical treatment (mild), or if it did necessitate medical treatment, the treatment was simple (moderate-like a patient who failed the process who eventually decided to get the knee replacement that he or she was planning before the process).
4. Why can’t I be on certain medicines during the procedure?
Certain sorts of medicines will negatively sway the stem cells. Furthermore, we usually see that many prescription medicines will lessen stem cell number.
5. How painful is the process for implanting stem cells?
It is somewhat as painful as a typical shot in a doctor’s clinic.
6. When can I expect to feel better and see the results?
The results should become obvious over 1-3 months, but at times can take as long as 6-9 months.
7. When can I return to normal activity?
This depends on the kind of procedure. However, all of our techniques are designed to promote as much early activity as possible.
Liver disorder patients treated with stem cells typically observe improvements in the following areas:
- Enhanced liver function and related symptoms
- Vatical bleeding
- Hepatic coma
- Mesenchymal Stem Cells segregate into parenchymal hepatocytes to improve liver function. It is assessed that approximately 2-3 × 1010 healthy parenchymal hepatocytes are required to maintain normal function of an adult liver. In severe fibrotic or cirrhotic livers, the quantity of hepatocytes is considerably reduced. Trans-differentiation of donor MSCs to become parenchymal hepatocytes has been recurrently demonstrated.
- MSCs avert the liver from undergoing fibrogenesis by secreting a multiplicity of cytokines such as HGF, interleukin (IL)-6 and -10 and.
MSCs might dissolve fibrosis directly. There was evidence signifying that MSCs were able to create the matrix metalloproteinase (MMPs), an enzyme adept of degrading the extracellular matrix, which assuages hepatic cirrhosis directly.
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