Optic nerve Neuropathy is frequently seen in patients already suffering from Multiple sclerosis, neuromyelitis optica spectrum disorder. Anti-myelin oligodendrocyte glycoprotein-associated disease, and other systemic autoimmune disorders. Some of the prominent symptoms include Pain in the movement of eyeballs, vision loss in eyes, peripheral vision loss, and loss of color perception with colors appearing less vibrant than usual. Some of the preexisting conditions behind the disease could be Infections such as Lyme disease, bacterial infections diseases such as sarcoidosis, and lupus as well.
Currently available treatments for Optic Nerve neuropathy.
A substantial dose of steroids is frequently used to treat optic nerve neuropathy originating due to the presence of Multiple Sclerosis. However, according to reports on the already conducted research, there did not appear to be a long-term benefit from a single course of intravenous steroid treatments. The reports also showcased that those treated with oral steroids had worse outcomes vs. intravenous steroids or no treatment at all.
Chemotherapy and autologous hematopoietic Stem Cell Transplant
A significant focus of research in Multiple sclerosis and related neurological disorders is immunosuppression with the side of chemotherapy and immune-depleting antibodies followed by an autologous hematopoietic stem cell transplant. The rationale behind the treatment is that inflammatory T cells that enter and infiltrate the central nervous system and then recirculate in the cerebrospinal fluid. T cell clones in the intrathecal compartment in active relapsing-remitting MS and found that an HSCT removed most of them, establishing new immune repertoire in both intrathecal and peripheral blood compartments. Significant complications in doing so limit this therapy.
For the promotion of neuroprotection in Optic nerve neuropathy and ‘of the inflammatory response and neuroprotection of glial cells and RGCs is vital. MSC therapy is a promising approach to reducing the severity of Optic nerve neuropathy caused by Multiple sclerosis by triggering remyelination. Most of these indications are based on studies conducted in mouse models and do not necessarily extrapolate to other models of Multiple Sclerosis. Recent research has also revealed that MSC’S are a tangible source for a decrease in inflammatory cytokines, reduced axonal loss, attenuated demyelination, and improved functional recovery in mice and rat models before disease onset. But even Mesenchymal cells lacked the ability to differentiate into neural phenotypes after being migrated into the central nervous system via the intravenous system.
Axon remyelination and MSC-EVs
In MS and related disorders, activated immune cells in inflammatory lesions damage myelin-producing oligodendrocytes, causing demyelination. Several studies have showcased that MSC EV’S can protect and promote the development of OLD and their precursor cells throughout the course of the disease. The study was done on mice models, but it brought forward several limitations to notice. But a general breakthrough in the research revealed that MSC-EVs boosted remyelination and increased mature oligodendrocyte and neuronal cell counts, leading to significantly improved learning ability in mice with prenatal brain injuries. Stem Cell Care India could be your best choice for Stem cell therapy of diseases like Optic Nerve Neuropathy in India. Stem cell Care India could provide one of the best stem cell treatments for conditions like Optic Nerve neuropathy. The Ace doctors and physicians in their team can devise treatment according to the patient’s comfort, ensuring the devised treatment schedule considers every unique necessity of the patient. If that is not all, Stem Cell Care India can also serve to clients from abroad; stem cell therapy provides a host of therapies, including physiotherapy as well as occupational and speech therapies. For Patients suffering from lifestyle diseases, Stem Cell Care India can also offer therapies that can alter lifestyles and help in quitting smoking as well as excessive alcohol intake. Their profound services are just a single call away.