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Stem Cell Treatment for Kidney Disorder

stem cell therapy

The kidneys -the two bean sized organs filter out wastes and fluid from your blood. When the kidneys cannot filter the blood the way it should, kidney diseases occur. Treatments like kidney transplants and dialysis are available. But, kidney transplants are often not a feasible option due to the non-availability of organ. Other kidney problems are kidney stones, kidney cysts, kidney injury and kidney infections.

People with high blood pressure and diabetes are at a higher risk of kidney disease. Each kidney contains about 1 millions tiny filtering units called nephrons. Kidney disease is caused when these nephrons is scarred or injured. In high blood pressure, the blood vessels of kidneys, heart and brain is damaged. This is especially dangerous to your kidneys.

Kidney disorders may be “acute” or “chronic”. Acute kidney failure occurs when the kidneys suddenly lose the ability to eliminate excess salts, fluids, and waste materials from the blood. The most common reasons of acute kidney failure are:

  • Acute Tubular Necrosis (ATN)
  • Severe or sudden dehydration
  • Toxic kidney injury from poisons or certain medications
  • Autoimmune kidney diseases, such as acute nephritic syndrome and interstitial nephritis
  • Urinary tract obstruction

An older person or an individual with long-term medical conditions have higher chances of acquiring acute kidney failure. The health problems include:

  • kidney disease
  • liver disease
  • diabetes, especially if it’s not well controlled
  • high blood pressure
  • heart failure
  • morbid obesity

If you’re ill or being treated in a hospital’s intensive care unit, you’re at an extremely high risk for acute kidney failure. Being the recipient of heart surgery, abdominal surgery, or a bone marrow transplant can also increase your risk.

Dysfunctional kidneys for more than 3 months are associated with chronic kidney disorders. It is called a ‘silent’ disease because it is asymptomatic. It is rooted in urinary tract infections, abnormal immune conditions, overdose of medications, inflammation, congenital birth defects, etc. Untreated kidney failure is a serious and fatal condition.

: Early detection and treatment can help people get the right treatment at the right time. The symptoms include:

Fatigue or weakness — a build-up of wastes or a shortage of red blood cells (anemia) can cause these problems when the kidneys begin to fail.

Swelling of the feet, ankles, hands, or face — fluid the kidneys can’t remove may stay in the tissues.

 

Ammonia breath or an ammonia or metal taste in the mouth — waste build-up in the body can cause bad breath, changes in taste, or an aversion to protein foods like meat.

Itching — waste build-up in the body can cause severe itching, especially of the legs.

Changes in urination — making more or less urine than usual, feeling pressure when urinating, changes in the colour of urine, foamy or bubbly urine, or having to get up at night to urinate.

Back or flank pain — the kidneys are located on either side of the spine in the back.

Shortness of breath — kidney failure is sometimes confused with asthma or heart failure, because fluid can build up in the lungs.

Loss of appetite

Nausea and vomiting

Kidney disease can be found through lab tests or by symptoms. High blood levels of creatinine and urea nitrogen (BUN) or high levels of protein in your urine suggest kidney disease. Diabetics should have a yearly urine test for microalbumin, small amounts of protein that don’t show up on standard urine protein test.

As a patient, you may be asked a lot of questions about any past kidney problems. The doctor will also ask whether you have a family history of kidney disease and what medicines you take, both prescription and over-the-counter drugs. The doctor will conduct test to take a look at your kidneys, such as an ultrasound or CT scan. These tests can help your doctor measure the size of your kidneys, estimate blood flow to the kidneys, and see if urine flow is blocked. In some cases, your doctor may take a tiny sample of kidney tissue (biopsy) to help find out what caused your kidney disease.

Most often, kidney failure is a slow, progressive disease. Usually there are no severe tell-tale signs at the beginning stages of the disease. But you may experience:

Latest researches have revealed that MSCs can help restore Myelin of nervous system, improving symptoms and prolonging lives. Steroids and other disease modifying drugs cannot cover all the symptoms and are aimed to manage only specific symptoms. Again, the concern of critical side effects of drugs is also there. With MSC treatment, there is no such concern.

In StemCellCareIndia, we use the unique technology of Mesenchymal stem cells extracted from Wharton’s jelly (WJ) for treating kidney problems.  WJ-MSCs offer cost-effective and pain-free collection method that may be cryogenically stored, and are extremely favourable for tissue engineering purpose. They might help in the three prominent ways – prevent damage, repair damage and develop new medicines. The treatment will take place in multiple steps comprising of

  • Qualification for the treatment: Our experts will investigate your past medical history and symptoms to assess the severity of your condition. A series of tests will be performed to understand the stage of disease. As per the test results, our experts will counsel the patient for further process of the procedure.
  • Source Extraction: With guidance and approval from the physician, the source of extraction will be decided. In general, WJ-MSCs are the most potent allogenic sources available. Stem cells from a healthy person (the donor) are transferred to the patient’s body. A bone marrow donor is considered for allogenic stem cell transplantation. A scraping from the inside of the patient and his or her sibling’s cheek is tested to determine tissue type. An expert will examine to identity Human Leukocyte Antigens (HLAs). If the HLA on the donor cells are identical or similar, the transplant is more likely to be successful.
  • Laboratory Processing: The extracted samples will be sent to government approved cGMP laboratory for processing. The sample manipulation will take place in a state-of-art facility in compliance with the ISO and GMP standards and using the latest technologies. The client will receive a third party certificate from internationally accredited lab for quality purpose.
  • Stem Cell Implantation: Once the stem cells are ready to be implanted, the doctor will identify the most potent method of infusion based on the patient’s physical and mental well being.

 

Treatment Aftercare: The patients will be asked to visit the doctors for reclamation therapies such as regular check ups, counselling, etc for speedy recovery.

1.Are there symptoms of renal failure?

frequent trips to the restroom

loss of appetite

dry, itchy skin

swollen feet

muscle cramps

2.Are there tests that can detect kidney disease?

A doctor may first detect the condition through routine blood and urine tests. There are three tests to screen for kidney disease: a blood pressure measurement, a spot check for protein or albumin in the urine (proteinuria), and a calculation of glomerular filtration rate (GFR) based on a serum creatinine measurement. Measuring urea nitrogen in the blood provides additional information.

3.How long does a transplanted kidney work?

On average, a kidney transplant lasts between eight and 15 years. But some transplants last only a few weeks and some last 20 years. In general, kidneys from living donors last longer than those from cadaveric (deceased) donors.

4.What causes kidney failure?

There are several conditions that can lead to kidney disease, but the leading two causes are hypertension (high blood pressure) and diabetes.

5.What does it mean to be an ESRD patient?

End-stage renal disease (ESRD) occurs when kidney damage is so severe that dialysis or a kidney transplant is needed to control symptoms and prevent complications and death. This is total and permanent kidney failure. When the kidneys fail, the body retains fluids and harmful wastes build up poisoning the body.

6.What is dialysis?

Dialysis is the procedure for artificially replacing many functions performed by normal kidneys. It is necessary to replace kidney function when kidneys are no longer able to keep people healthy and safe. There are two common types of dialysis: hemodialysis and peritoneal dialysis.

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