Amyotrophic Lateral Sclerosis (ALS), often called Lou Gehrig’s disease after the renowned baseball player’s struggle with this disease and death in 1941 grabbed national attention. It is an incurable, progressive degenerative neurological disorder. The nerve cells of the brain and spinal cord that control voluntary muscle movement gradually decline for reasons unknown. The muscles waste away leading to paralysis and death of the person in 2-5 years time. The only neurons affected are the lower motor nerve cells which control a wide range of things like movement of limbs, swallowing, and even breathing.
Motor neurons run from brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons eventually leads to their death. When motor neurons die, the ability of the brain to start and control muscle movement is lost. This also affects a person’s ability to speak, eat, move and breathe. In ALS, the motor neurons that provide voluntary movements and muscle control are affected. Research has revealed a wealth of new scientific understanding about the physiology of this disease. Stem cell treatment has emerged as an effective treatment option for ALS.
The beginning of ALS may be so blurred that the symptoms are frequently ignored. The earliest symptoms may include:
slurred and nasal speech
difficulty chewing or swallowing
muscle weakness affecting an arm or a leg
spasms, cramps, or stiffness of muscles
Depending on the muscles in the body that are damaged first the early symptoms of ALS surface. Symptoms initially affect one of the legs and patients experience difficulty in running or walking, or they experience they are stumbling or tripping more often. The signs of disease first appear on hands or arms and they experience difficulty in pursuing simple tasks requiring manual agility such as writing, turning a key in a lock and other. Some patients notice speech problems.
ALS affects the upper motor neurons, which are in the brain, and the lower motor neurons, which are in the spinal cord and brainstem. Upper motor neuron degeneration generally causes spasticity (tightness in a muscle), while lower motor neuron degeneration causes muscle weakness, muscle atrophy (shrinkage of muscles) and twitching. These can occur in combination in ALS, as upper and lower motor neurons are being lost at the same time.
Though it usually strikes people in their late middle age, ALS can affect people of any age. It is characterized by persistent weakness or spasticity in an arm or leg. The problem originated in the muscles controlling speech or swallowing. People facing such issues cannot ignore the problem and must see a doctor.
To diagnose ALS, a neurologist will administer electromyogram (EMG) for the detection of nerve damage. Electromyogram (EMG)
- Nerve conduction study
- Magnetic resonance imaging (MRI)
- Blood and urine tests
- Spinal tap (lumbar puncture
- Muscle biopsy
Latest researches have revealed that MSCs can help restore Myelin of nervous system, improving symptoms and prolonging lives. Steroids and other disease modifying drugs cannot cover all the symptoms and are aimed to manage only specific symptoms. Again, the concern of critical side effects of drugs is also there. With MSC treatment, there is no such concern.
In StemCellCareIndia, we use the unique technology of Mesenchymal stem cells extracted from Wharton’s jelly (WJ) for treating MS. WJ-MSCs offer cost-effective and pain-free collection method that may be cryogenically stored, and are extremely favourable for tissue engineering purpose. They might help in the three prominent ways – prevent damage, repair damage and develop new medicines. The treatment will take place in multiple steps comprising of
Qualification for the treatment: Our experts will investigate your past medical history and symptoms to assess the severity of your condition. A series of tests will be performed to understand the stage of disease. As per the test results, our experts will counsel the patient for further process of the procedure.
Source Extraction: With guidance and approval from the physician, the source of extraction will be decided. In general, WJ-MSCs are the most potent allogenic sources available. Stem cells from a healthy person (the donor) are transferred to the patient’s body. A bone marrow donor is considered for allogenic stem cell transplantation. A scraping from the inside of the patient and his or her sibling’s cheek is tested to determine tissue type. An expert will examine to identity Human Leukocyte Antigens (HLAs). If the HLA on the donor cells are identical or similar, the transplant is more likely to be successful.
Laboratory Processing: The extracted samples will be sent to government approved cGMP laboratory for processing. The sample manipulation will take place in a state-of- art facility in compliance with the ISO and GMP standards and using the latest technologies. The client will receive a third party certificate from internationally accredited lab for quality purpose.
Stem Cell Implantation: Once the stem cells are ready to be implanted, the doctor will identify the most potent method of infusion based on the patient’s physical and mental well being. The risk of treatment by Adult Autologous Stem Cell is minimal and limited to the normal risks of surgical intervention. Because the used cells are patient’s own, there is no risk of rejection or side effects. The treatment by own steam cells can significantly slow down the ALS symptoms and prolong patient’s life.
Treatment Aftercare: The patients will be asked to visit the doctors for some tests to analyse the improvement. Suggestive rehabilitation programs may include behaviour and emotional development, communication and social interaction, self-regulation, cognitive and adaptive skills.
1,What Is ALS?
ALS is that the sickness poignant the brain cells popularly referred to as neurons connecting brain with alternative elements of the body. These neurons act as messengers to transmit signals from brain to muscles to permit the voluntary movements of the body. thanks to some external or internal factors, these cells die or degenerate thereby losing the power to transmit signals to muscles. This cause the muscles to be weak resulting in palsy.
2.What Causes ALS ?
Although, ALS has been terribly current worldwide, scientists square measure still group action to grasp the precise cause and mechanism for ALS. There are to this point numerous studies to analyse completely different sides, that can be joined up with ALS. though studies square measure correlating the sickness for many genetic variations, there’s nonetheless way to be understood.
3.Is ALS joined to the setting ?
Clinical studies to this point haven’t found definitive environmental factors which will be joined with ALS except some generalized studies relating it to the potential exposure of bound chemicals like lead or mercury.
4.Is ALS equally common in each the genders ?
ALS, that has been induced thanks to some environmental factors, is determined to be slightly a lot of common in men than in ladies. but it’s conjointly been according recently that the distinction is decreasing over the time. At a similar time, familial ALS i.e. ALS related to the genetic variations is equally common in each the genders.
5.Is ALS associated with age?
ALS is usually age related; most of the individuals resolve that they’re suffering with ALS after they are between 55-75 years mature.
6.How long do individuals with ALS live?
Most of the individuals with ALS have determined to be living for three to five years when the symptoms will develop. though the precise lifetime of the person with ALS are associated with age.
7.Can ALS be familial ?
It has been determined that nearly} about 5-10% of the whole ALS cases square measure familial ALS i.e. they’re largely caused thanks to the defect within the factor that is usually referred to as “SOD1”
8.What is a efferent neuron disease?
ALS falls underneath a bunch of conditions referred to as efferent neuron sickness. In ALS, muscles concerned within the voluntary movements of each higher and lower body square measure affected. On a median, ALS usually accounts for the eighty fifth of efferent neuron diseases.
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